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microRNA-181b targets MLK2 in HL-60 cells 被引量：20

microRNA-181b targets MLK2 in HL-60 cells
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摘要 microRNAs(miRNAs) play critical roles in many different cellular processes,including metabolism,apoptosis,differentiation and development.We showed miR-181b to be highly expressed in acute myeloid leukemia(AML).Furthermore,miR-181b contributed to proliferation of AML cells by targeting MLK2.Our results demonstrated that miR-181b plays an important role in the biology of AML and may be useful in developing therapies targeting miRNAs. microRNAs(miRNAs) play critical roles in many different cellular processes,including metabolism,apoptosis,differentiation and development.We showed miR-181b to be highly expressed in acute myeloid leukemia(AML).Furthermore,miR-181b contributed to proliferation of AML cells by targeting MLK2.Our results demonstrated that miR-181b plays an important role in the biology of AML and may be useful in developing therapies targeting miRNAs.
作者 CHEN Hong1,CHEN Qun2,FANG Ming3 & MI Yan1 1 The First Affiliated Hospital of Harbin Medical University,Harbin 150101,China 2 Harbin Acheng District People’s Hospital,Harbin 150300,China 3 Graduate Department of Harbin Medical University,Harbin 150001,China
出处 《Science China(Life Sciences)》 SCIE CAS 2010年第1期101-106,共6页 中国科学（生命科学英文版）
关键词 microRNA-181b MLK2 AML HL-60 PROLIFERATION APOPTOSIS microRNA-181b MLK2 AML HL-60 proliferation apoptosis
分类号 Q522 [生物学—生物化学]
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参考文献38

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同被引文献86

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Science China(Life Sciences)
2010年 第1期

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