摘要
Cyclin Y (CCNY) is a key cell cycle regulator that acts as a growth factor sensor to integrate extracellular signals with the cell cycle machinery. The expression status of CCNY in lung cancer and its clinical significance remain unknown. The data indicates that CCNY may be deregulated in non-small cell lung cancer, where it may act to promote cell proliferation. These studies suggest that CCNY may be a candidate biomarker of NSCLC and a possible therapeutic target for lung cancer treatment.
Cyclin Y (CCNY) is a key cell cycle regulator that acts as a growth factor sensor to integrate extracellular signals with the cell cycle machinery. The expression status of CCNY in lung cancer and its clinical significance remain unknown. The data indicates that CCNY may be deregulated in non-small cell lung cancer, where it may act to promote cell proliferation. These studies suggest that CCNY may be a candidate biomarker of NSCLC and a possible therapeutic target for lung cancer treatment.
作者
YUE WenTao1, ZHAO XiaoTing1, ZHANG LiNa1, LIU ZhiDong2, MA Li1, JIA WenYun1, QIAN Zhe1, ZHANG ChunYan1, WANG Yue1, YANG XueHui1 & XU ShaoFa2 1 Department of Cellular Biology, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China
2 Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China
基金
supported by the Beijing Novel Program (to Yue WenTao) (Grant No. 2006B34)
the Scientific Research Foundation for the Returned Overseas Chinese Scholars
the State Education Ministry and Beijing Research Foundation for Excellent Talents (to Yue Wentao) (Grant No. 20061D03)
