期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Overcoming multidrug resistance(MDR) in cancer by nanotechnology 被引量：5

Overcoming multidrug resistance(MDR) in cancer by nanotechnology
原文传递
导出
摘要 The emerging nanotechnology-based drug delivery holds tremendous potential to deliver chemotherapeutic drugs for treatment of multidrug resistance(MDR) cancer.This drug delivery system could improve the pharmacokinetic behavior of antitumor drugs,deliver chemotherapeutic drugs to target sites,control release of drugs,and reduce the systemic toxicity of drugs in MDR cancer.This review addresses the use of nanotechnology to overcome MDR classified on the bases of the fundamental mechanisms of MDR and various approaches to deliver drugs for treatment of MDR cancer. The emerging nanotechnology-based drug delivery holds tremendous potential to deliver chemotherapeutic drugs for treatment of multidrug resistance(MDR) cancer.This drug delivery system could improve the pharmacokinetic behavior of antitumor drugs,deliver chemotherapeutic drugs to target sites,control release of drugs,and reduce the systemic toxicity of drugs in MDR cancer.This review addresses the use of nanotechnology to overcome MDR classified on the bases of the fundamental mechanisms of MDR and various approaches to deliver drugs for treatment of MDR cancer.
作者 BU HuiHui,GAO Yu & LI YaPing Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China
出处 《Science China Chemistry》 SCIE EI CAS 2010年第11期2226-2232,共7页 中国科学（化学英文版）
基金 The National Basic Research Program of China (2010CB934000) the National Natural Science Foundation of China (30925041) Shanghai Nanomedicine Program (0852nm05700)
关键词 NANOTECHNOLOGY nanoparticles MULTIDRUG resistance CHEMOTHERAPEUTIC drugs CANCER drug delivery system nanotechnology nanoparticles multidrug resistance chemotherapeutic drugs cancer drug delivery system
分类号 R319 [医药卫生—基础医学]
  • 相关文献

参考文献77

  • 1阎洲,裴元英.紫杉醇肺靶向微球的制备及体内外评价[J].中国临床药学杂志,2006,15(4):226-231. 被引量：7
  • 2Sunita Yadav,Lilian E. Vlerken,Steven R. Little,Mansoor M. Amiji.Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells[J]. Cancer Chemotherapy and Pharmacology . 2009 (4)
  • 3Dongin Kim,Eun Seong Lee,Kyeongsoon Park,Ick Chan Kwon,You Han Bae.Doxorubicin Loaded pH-sensitive Micelle: Antitumoral Efficacy against Ovarian A2780/DOXR Tumor[J]. Pharmaceutical Research . 2008 (9)
  • 4Ghazal Mohajer,Eun Seong Lee,You Han Bae.Enhanced Intercellular Retention Activity of Novel pH-sensitive Polymeric Micelles in Wild and Multidrug Resistant MCF-7 Cells[J]. Pharmaceutical Research . 2007 (9)
  • 5Jos MA Kuijlen,Jan Jakob A Mooij,Inge Platteel,Eelco W Hoving,Winette TA Graaf,Mark M Span,Harry Hollema,Wilfred FA Dunnen.TRAIL-receptor expression is an independent prognostic factor for survival in patients with a primary glioblastoma multiforme[J]. Journal of Neuro - Oncology . 2006 (2)
  • 6Klaus-Michael Debatin.Apoptosis pathways in cancer and cancer therapy[J]. Cancer Immunology, Immunotherapy . 2004 (3)
  • 7Asharani PV,Xinyi N,Hande MP,Valiyaveettil S.DNA damage and p53-mediated growth arrest in human cells treated with platinum nanoparticles. Nanomedicine (Lond) . 2010
  • 8Foldbjerg R,Dang DA,Autrup H.Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line,A549. Archives of Toxicology . 2010
  • 9Kim D,Lee ES,Oh KT,Gao ZG,Bae YH.Doxorubicin-loaded polymeric micelle overcomes multidrug resistance of cancer by double- targeting folate receptor and early endosomal pH. Small . 2008
  • 10Lee ES,Gao Z,Kim D,Park K,Kwon IC,Bae YH.Super pH-sensitive multifunctional polymeric micelle for tumor pHe spe- cific TAT exposure and multidrug resistance. Journal of Controlled Release . 2008

二级参考文献7

  • 1施斌,裴元英.紫杉醇及其制剂研究进展[J].中国临床药学杂志,2004,13(6):389-392. 被引量：14
  • 2孙燕.肺癌化疗的策略和实施[J].中国实用内科杂志,1996,16(4):193-194. 被引量：3
  • 3Rowinsky EK, Cazenave LA, Donehowe RC. Taxol : a novel investigational antimicrotubule agent[J]. J Natl Cancer Inst, 1990,82(15) : 124.
  • 4Singla AK, Garg A, Aggarwal D. Paclitaxel and its formulations[J]. Int J Pharm,2002,235( 1 - 2) : 179.
  • 5Fonseca C, Simones S, Gaspar R. Paclitaxel-loaded PLGA napoparticles: preparation, physicochemical characterization and in vivo antitumot activity[J]. J Controlled Release,2002,832(2):273.
  • 6Prior S,Camazo C,Irache JM, et al. Gentamicin encapsulation in PLA/PLGA microspheres in view of treating Brucella infections [ J ]. Int J Pharm, 200,196( 1 ) : 115.
  • 7陆彬．药物新剂型和技术[M]．北京：人民卫生出版社，1998：229—301．

共引文献6

同被引文献27

引证文献5

二级引证文献10

Science China Chemistry
2010年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部