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酪氨酸激酶抑制剂厄洛替尼的研究进展 被引量：5

Advances in research on tyrosine kinase inhibitor-erlotinib
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摘要 厄洛替尼是一种小分子选择性表皮生长因子受体酪氨酸激酶抑制剂。临床用于一线化疗失败的局部晚期或转移性非小细胞肺癌的治疗。本文对厄洛替尼的药理作用、药动学特征、药物相互作用、毒副作用以及临床研究等作一综述。 厄洛替尼是一种小分子选择性表皮生长因子受体酪氨酸激酶抑制剂。临床用于一线化疗失败的局部晚期或转移性非小细胞肺癌的治疗。本文对厄洛替尼的药理作用、药动学特征、药物相互作用、毒副作用以及临床研究等作一综述。
作者 余奇 郭澄
机构地区 上海交通大学附属第六人民医院药剂科
出处 《药学服务与研究》 CAS CSCD 2010年第6期453-457,共5页 Pharmaceutical Care and Research
基金 上海交通大学医学院科研基金资助项目(No.JYY0909)
关键词 厄洛替尼 受体 表皮生长因子 蛋白质酪氨酸激酶 癌 非小细胞肺 胰腺肿瘤 综述 erlotinib receptor,epidermal growth factor protein-tyrosine kinase carcinoma,non-small-cell lung pancreatic neoplasms review
分类号 R9 [医药卫生—药学]
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参考文献22

  • 1Karrison T G,Maitland ML,Stadler W M,et al.Design ofphaseⅡcancer trials using a continuous endpoint of changein tumor size:application to a study of sorafenib and erlotinibin non-small-cell lung cancer. Journal of the National Cancer Institute . 2007
  • 2van Erp NP,Gelderblom H,Guchelaar HJ.Clinical pharma-cokinetics of tyrosine kinase inhibitors. Cancer Treatment Reports . 2009
  • 3Rocha-Li ma C M,Raez L E.Erlotinib (tarceva)for the treat-ment of non-small-cell lung cancer and pancreatic cancer. P T . 2009
  • 4Jackman D M,Yeap B Y,Lindeman N I,et al.PhaseⅡclinical trial of chemotherapy-naive patients≥70 years of agetreated with erlotinib for advanced non-small-cell lung cancer. Journal of Clinical Oncology . 2007
  • 5Quintela-Fandino M,Le Tourneau C,Duran I,et al.PhaseⅠcombination of sorafenib and erlotinib therapy in solidtumors:safety,pharmacokinetic,and pharmacodynamicevaluation from an expansion cohort. Molecular Cancer Therapeutics . 2010
  • 6JANMAT ML,Giaccone G.Small~Molecule Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors. The Oncologist . 2003
  • 7Giaccone G,Gallegos RM,Le CT,et al.Erlotinib for frontline treatment of advanced non-small cell lung cancer:a phase II study. Clinical Cancer Research . 2006
  • 8Frank Bergmann,Irene Esposito,Peter Schirmacher.Pancreatic cancer–Pathology[J].The Chinese-German Journal of Clinical Oncology,2007,6(2):95-101. 被引量：2
  • 9Kumar A,Petri ET,Halmos B, et al.Structure and clinical relevance of the epidermal growth factor receptor in human cancer. Journal of Clinical Oncology . 2008
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二级参考文献98

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药学服务与研究
2010年 第6期

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