摘要
AIM:To evaluate the effect of acute stress,hydrochloric acid,ethanol,aspirin,and prednisolone on the intercellular spaces of the esophageal epithelium.METHODS:Part -RESULTS:(1) The f ive damaging factors produced no lesions or inflammation in esophageal mucosa of rats under either gross or routine histological inspections.Esophageal epithelial intercellular space diameters in stress and aspirin groups were significantly greater,nearly three or two-fold respectively,than those in their corresponding control groups (stress model:0.38 ± 0.05 μm vs 0.13 ± 0.02 μm,P < 0.01;aspirin model:0.32 ± 0.12 μm vs 0.19 ± 0.05 μm,P < 0.01).Neither intragastric administration of hydrochloric acid or ethanol,nor hypodermic injection of prednisolone produced DIS compared with their corresponding control groups (hydrochloric acid model:0.24 ± 0.03 μm vs 0.19 ± 0.05 μm,P > 0.05;ethanol model:0.25 ± 0.10 μm vs 0.19 ± 0.05 μm,P > 0.05;prednisolone model:0.20 ± 0.03 μm vs 0.14 ± 0.03 μm,P > 0.05);and (2) No significant difference in the intercellular space diameters was observed between the group pretreated with esomeprazole and the control group,in both the stress and aspirin models (stress model:0.35 ± 0.05 μm vs 0.37 ± 0.05 μm,P > 0.05;aspirin model:0.24 ± 0.02 μm vs 0.27 ± 0.03 μm,P > 0.05).CONCLUSION:Acute stress and aspirin can induce DIS of the esophageal epithelium in rats,and it is not correlated with acid reflux.
AIM:To evaluate the effect of acute stress,hydrochloric acid,ethanol,aspirin,and prednisolone on the intercellular spaces of the esophageal epithelium.METHODS:Part -RESULTS:(1) The f ive damaging factors produced no lesions or inflammation in esophageal mucosa of rats under either gross or routine histological inspections.Esophageal epithelial intercellular space diameters in stress and aspirin groups were significantly greater,nearly three or two-fold respectively,than those in their corresponding control groups (stress model:0.38 ± 0.05 μm vs 0.13 ± 0.02 μm,P < 0.01;aspirin model:0.32 ± 0.12 μm vs 0.19 ± 0.05 μm,P < 0.01).Neither intragastric administration of hydrochloric acid or ethanol,nor hypodermic injection of prednisolone produced DIS compared with their corresponding control groups (hydrochloric acid model:0.24 ± 0.03 μm vs 0.19 ± 0.05 μm,P > 0.05;ethanol model:0.25 ± 0.10 μm vs 0.19 ± 0.05 μm,P > 0.05;prednisolone model:0.20 ± 0.03 μm vs 0.14 ± 0.03 μm,P > 0.05);and (2) No significant difference in the intercellular space diameters was observed between the group pretreated with esomeprazole and the control group,in both the stress and aspirin models (stress model:0.35 ± 0.05 μm vs 0.37 ± 0.05 μm,P > 0.05;aspirin model:0.24 ± 0.02 μm vs 0.27 ± 0.03 μm,P > 0.05).CONCLUSION:Acute stress and aspirin can induce DIS of the esophageal epithelium in rats,and it is not correlated with acid reflux.
