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γ-Hydroxy-α,β-acetylenic esters:asymmetric syntheses and applications 被引量:1

γ-Hydroxy-α,β-acetylenic esters:asymmetric syntheses and applications
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摘要 γ-Hydroxy-α,β-acetylenic esters are versatile synthetic precursors to many organic compounds.This paper reviews the synthesis of chiral γ-hydroxy-α,β-acetylenic esters by asymmetric reduction of γ-oxo-α,β-acetylenic esters,enantioselective addition to aldehydes in the presence of chiral catalysts,and diastereoselective addition to chiral aldehydes.The preparation of racemic γ-hydroxy-α,β-acetylenic esters is also included.Examples are provided for the application of γ-hydroxy-α,β-acetylenic esters in organic synthesis. γ-Hydroxy-α,β-acetylenic esters are versatile synthetic precursors to many organic compounds.This paper reviews the synthesis of chiral γ-hydroxy-α,β-acetylenic esters by asymmetric reduction of γ-oxo-α,β-acetylenic esters,enantioselective addition to aldehydes in the presence of chiral catalysts,and diastereoselective addition to chiral aldehydes.The preparation of racemic γ-hydroxy-α,β-acetylenic esters is also included.Examples are provided for the application of γ-hydroxy-α,β-acetylenic esters in organic synthesis.
出处 《Science China Chemistry》 SCIE EI CAS 2010年第1期21-35,共15页 中国科学(化学英文版)
基金 support of Sichuan University support of the US National Science Foundation (CHE-0717995) the donors of the Petroleum Research Fund-administered by the American Chemical Society
关键词 γ-hydroxy-α β-acetylenic ESTER ASYMMETRIC ENANTIOSELECTIVE DIASTEREOSELECTIVE γ-hydroxy-α β-acetylenic ester asymmetric enantioselective diastereoselective
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