摘要
Unique endoperoxide moiety of artemisinin and its derivatives has been considered the functionality exhibiting highly potent antimalarial and anticancer activities.To investigate the mechanisms of their biological actions,development of suitable molecular probes including biotinylated derivatives is of extreme significance.The synthesis and preliminary biological assessment of four new biotinylated artemisinin derivatives have been reported in this work.
Unique endoperoxide moiety of artemisinin and its derivatives has been considered the functionality exhibiting highly potent antimalarial and anticancer activities.To investigate the mechanisms of their biological actions,development of suitable molecular probes including biotinylated derivatives is of extreme significance.The synthesis and preliminary biological assessment of four new biotinylated artemisinin derivatives have been reported in this work.
作者
PAN QiYu1,2,WANG ShaoZhong1,LU JinJian3,MENG LingHua3 & YAO ZhuJun1,2 1Nanjing National Laboratory of Microstructures(NNLM),School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210093,China
2Joint Laboratory of Green Chemistry,Department of Chemistry,University of Science and Technology of China,Hefei 230026,China
3State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 201203,China.
基金
supported by the National Natural Science Foundation of China (Grant Nos. 20672128, 90713044 and 30701026)
CAS (Grant No. KSCX2-YW-R23)
