摘要
Three series of forty-nine novel 4-(3-trifluoromethylphenyl)-2H-pyridazin-3-one derivatives are designed,synthesized,and evaluated through a Spirodela polyrrhiza test and a greenhouse test.Some compounds show 】 80% chlorophyll inhibition of Spirodela polyrrhiza at 10 μg/mL and exhibit some herbicidal activities against Digitaria adscendens in the pre-emergence treatment at a rate of 150 g/ha.Moreover,the study of the structure-activity relationship(SAR) suggests that the appropriate bulky substituent at the right position is critical for the bleaching and herbicidal activities,which may be useful for the future design of new compounds.
Three series of forty-nine novel 4-(3-trifluoromethylphenyl)-2H-pyridazin-3-one derivatives are designed,synthesized,and evaluated through a Spirodela polyrrhiza test and a greenhouse test.Some compounds show > 80% chlorophyll inhibition of Spirodela polyrrhiza at 10 μg/mL and exhibit some herbicidal activities against Digitaria adscendens in the pre-emergence treatment at a rate of 150 g/ha.Moreover,the study of the structure-activity relationship(SAR) suggests that the appropriate bulky substituent at the right position is critical for the bleaching and herbicidal activities,which may be useful for the future design of new compounds.
作者
XU Han,HU XuHong,ZHU YouQuan,ZOU XiaoMao,LIU Bin,HU FangZhong & YANG HuaZheng State Key Laboratory of Elemento-Organic Chemistry
Research Institute of Elemento-organic Chemistry,College of Chemistry,Nankai University,Tianjin 300071,China National Engineering Research Center of Pesticides(Tianjin),Nankai University,Tianjin 300071,China
基金
support from the China 973 Program (Grant No.2010CB126103)
the National Natural Science Foundation of China (Grant Nos.20572054 & 20972081)
