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HBV前-C区和BCP区变异与肝细胞癌的相关性分析

Correlation of hepatocellular carcinoma and the mutations of precore and basic core promoter regions of hepatitis B virus
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摘要 目的探讨HBV前-C区G1896A和BCP区A1762T/G1764A变异与肝细胞癌(HCC)的关系及其可能的机制。方法选择于青岛市传染病医院住院的HBV DNA>104拷贝/ml的慢性HBV感染者82例,其中慢性乙型肝炎(CHB)29例,乙型肝炎肝硬化(LC)27例,HBV相关肝细胞癌(HCC)26例,采用实时荧光PCR法检测其HBV前-C区1896位变异和BCP区1762/1764位变异,并采用ELISA法检测血清肿瘤坏死因子α(TNF-α)水平。结果 HCC组和LC组前-C区G1896A和BCP区A1762T/G1764A变异率、血清TNF-α水平均显著高于CHB组,但HCC组和LC组间无显著差异。前-C区G1896A和BCP区A1762T/G1764A变异者血清TNF-α水平均显著高于非变异组。结论 HBV前-C区G1896A和BCP区A1762T/G1764A变异与HCC形成有关,机制是否与HBV变异和TNF-α水平间的因果关系相关,有待进一步研究。 目的探讨HBV前-C区G1896A和BCP区A1762T/G1764A变异与肝细胞癌(HCC)的关系及其可能的机制。方法选择于青岛市传染病医院住院的HBV DNA>104拷贝/ml的慢性HBV感染者82例,其中慢性乙型肝炎(CHB)29例,乙型肝炎肝硬化(LC)27例,HBV相关肝细胞癌(HCC)26例,采用实时荧光PCR法检测其HBV前-C区1896位变异和BCP区1762/1764位变异,并采用ELISA法检测血清肿瘤坏死因子α(TNF-α)水平。结果 HCC组和LC组前-C区G1896A和BCP区A1762T/G1764A变异率、血清TNF-α水平均显著高于CHB组,但HCC组和LC组间无显著差异。前-C区G1896A和BCP区A1762T/G1764A变异者血清TNF-α水平均显著高于非变异组。结论 HBV前-C区G1896A和BCP区A1762T/G1764A变异与HCC形成有关,机制是否与HBV变异和TNF-α水平间的因果关系相关,有待进一步研究。
作者 李建忠 柳富会 侯青顺 李晓斐
机构地区 青岛海慈医疗集团 青岛市传染病医院
出处 《中国肝脏病杂志（电子版）》 CAS 2010年第4期20-22,共3页 Chinese Journal of Liver Diseases：Electronic Version
关键词 癌 肝细胞 肝炎病毒 乙型 变异 肿瘤坏死因子Α Carcinoma,hepatocellular Hepatitis B virus Mutation Tumor necrosis factor α
分类号 R735.7 [医药卫生—肿瘤]
  • 相关文献

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中国肝脏病杂志（电子版）
2010年 第4期

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