机械通气下应用长托宁抢救重度有机磷中毒的效果观察与护理

The effect and care of using penehyclidine and mechanical ventilation to rescue severe organophosphate poisoning patients

目的探讨机械通气下应用长托宁抢救重度有机磷农药中毒的效果观察与护理。方法80例急性有机磷农药中毒患者随机分为长托宁组40例和阿托品组40例,2组机械通气方式和胆碱能复能剂应用相同,比较2组的疗效。结果长托宁组抢救成功率95%,明显高于阿托品组的75%,差异有统计学意义(p<0.05);长托宁组胆碱酯酶活性恢复时间比阿托品组快,用药总量及用药次数比阿托品组少、呼吸机使用时间比阿托品组短,差异均有统计学意义(p<0.01)。结论机械通气下应用长托宁能提高重度有机磷农药中毒的抢救成功率,降低死亡率及不良反应发生率。

Objective:To Explore the effect and care of using mechanical ventilation and Penehyclidine to rescue severe organophosphorus pesticide poisoning.Methods:80 cases of severe organophosphorus pesticide poisoning were randomly divided into Penehyclidine group and atropine group with 40 cases each,applying the same kind of mechanical ventilation mode and cholinergic rehabilitation drug in the two groups,compare the effect between the two groups.Results:The survival rate in the Penehyclidine group was 95%,while atropine group was only 75%,and the difference was statistically significant(p<0.05).For the time for cholinesterase activity retrieval,the Penehyclidine group was faster than the atropine,and the total drug medication less than atropine group,ventilator-time shorter than the atropine group,the difference was statistically significant(p<0.01).Conclusion:Under the application of mechanical ventilation,Penehyclidine can increase the survival rate of the severe organophosphorus pesticide poisoning,decrease the mortality and incidence of adverse reactions.