Survivin在口腔颌面部上皮性肿瘤中的研究进展

Advances in research of survivin in oral-maxillofacial epithelial tumors

Survivin是近年发现的结构独特的凋亡抑制蛋白家族成员,具有抑制细胞凋亡、调节细胞有丝分裂的双重功能。Survivin具有肿瘤特异性,在正常成人组织中少见表达却高表达于多种肿瘤组织且与肿瘤细胞的浸润和病人的不良预后密切相关。本文对Survivin的生物学功能及其与口腔颌面部上皮性肿瘤关系的研究进展进行综述。

Survivin is a member of the inhibitor of apoptosis protein (IAP) family, which is discovered recently, and it has special structure. It is a bifunctional protein that suppresses apoptosis and regulation of cell division. Survivin is a tumor-specific antiapoptosis factor which is undetectable in adult normal tissues. However, its expression in all the most common human tumors has been associated with increased aggressiveness and decreased patient survival. In this paper, the advances in research of Survivin in oral-maxillofacial epithelial tumors were summarized and the function of survivin in tumors were discussed.