胸腹水中唾液酸含量在鉴别良恶性疾病上的价值

Role of sialic content in effusions in differentiation of benign from malignat(Abstract)

本文测定恶性、炎性和肝硬化3组胸腹水中的总唾液酸(TotalSialic Acid TSA)和脂质结合唾液酸(Lipid-bound Sialic Acid LSA)含量,结果表明恶性组和炎性组的 TSA 和 LSA 明显高于肝硬化组,但恶性组和炎性组的 TSA 和 LSA 则无明显差异。恶性、炎性和肝硬化组的 TSA 值分别为499.52±183.98mg/L、508.68±208.79mg/L 和117.71±70.46mg/L;LSA则分别为146.28±103.62mg/L、115.26±72.13mg/L 和58.90±35.46mg/L。以肝硬化组的 TSA+2SD 作为恶性组和肝硬化组的鉴别值,其敏感性为88%,特异性为90.47%,有效性为89.13%。LSA 则无鉴别价值。

The Total Sialic Acid(TSA)and Lpid-bound Sialic Acid(LSA)con- centrations in ascitic and pleural effusions were determined in 25 various neoplasms,19 inflammatory and 21 patients with cirrhosis.The TSA level was significantly higher in cancer cases(499.52±183.93mg/L)and inflammatry(508.68+208.79mg/L)than in cirrhotic(117.71±70.46mg/L), (P<0.01,P<0.05),but no difference in cancer and inflammatory(P> 0.05).The optimal value for discrimination was 258mg/L for TSA in cancer and cirrhotic.In this study the appropriate values of sensitivity, specificity and effectiveness of TSA in effusions for cancer and cirrhotic obtained were 88%,90.47% and 89.13% respectively.