卡介菌多糖核酸与曲安奈德治疗溃疡型口腔扁平苔藓疗效比较

Observation on the therapeutic effect of BCG-PSN and triamcinolone acetonide on ulcerative oral lichen planus

目的评价卡介菌多糖核酸与曲安奈德治疗溃疡型口腔扁平苔藓(OLP)的疗效。方法选择2008年11月至2009年9月南阳市口腔医院黏膜科溃疡型OLP患者31例,随机分为卡介菌多糖核酸组(16例)与曲安奈德组(15例)。分别于口腔病损部位黏膜下封闭注射卡介菌多糖核酸和曲安奈德,每周1次,4～6次为1个疗程。随访6个月,观察疗效及复发情况。结果治疗1个疗程后,卡介菌多糖核酸组治疗总有效率为87.5%,曲安奈德组治疗总有效率为73.3%,二者差异无统计学意义;随访6个月,卡介菌多糖核酸组总复发率为50.0%,曲安奈德组总复发率为90.9%,两组差异有统计学意义(P<0.05)。结论局部采用卡介菌多糖核酸和曲安奈德封闭治疗溃疡型OLP均疗效显著,卡介菌多糖核酸治疗后复发少于曲安奈德。

Objective To evaluate the therapeutic effect of BCG-PSN and triamcinolone acetonide on ulcerative oral lichen planus(OLP). Methods From November 2008 to September 2009,Department of Periodontal and Oral Mucosal Disease,Nanyang Stomatological Hospital,31 patients with ulcerative OLP were chosen and randomly divided into BCG-PSN group(16 cases)and triamcinolone acetonide group(15 cases). The patients were given closed injection of BCG-PSN and triamcinolone acetonide under oral submucous lesion site respectively,once a week,4 to 6 times for a course of treatment. Observe the efficacy and recurrence after 6-month follow-up. Results After a course of treatment,total effective rate in BCG-PSN group was 87.5%,and that of triamcinolone acetonide group was 73.3%,the difference being not statistically significant. After 6 months the total recurrence rate of BCG-PSN group was 50.0%,and in triamcinolone acetonide group it was 90.9%,being with significant difference. Conclusion Partial closure of BCG-PSN and triamcinolone acetonide treatment for ulcerative OLP has significant effect,and the relapse rate is lower in the BCG-PSN group than in the triamcinolone acetonide group.