佛山市南海区407例出生缺陷监测资料分析

407 Cases Analysis of Birth Defects Surveillance in Nanhai of Fushan City

目的分析广东省佛山市南海区出生缺陷发生的种类及相关因素,了解出生缺陷变化趋势,探讨干预措施。方法对2002年10月1日～2006年9月30日在佛山市南海区市级2家医院住院分娩的孕满28周至出生后7天的围生儿进行出生缺陷监测,分析出生缺陷发生率、类别、构成比及相关因素。结果 2003～2006年期间监测医院共出生围生儿21593例,其中有出生缺陷407例,出生缺陷发生率呈逐年增高趋势。在407例出生缺陷儿中,单发畸形369例,多发畸形38例。出生缺陷前5位畸形依次为:多指(趾)、先天性心脏病、唇腭裂、尿道下裂、并指(趾)。出生缺陷的发生率农村明显高于城市(χ2=22.25,P<0.001);出生缺陷发生的性别分布为男性高于女性,经检验有显著性差异(χ2=13.88,P<0.01)。结论佛山市南海区出生缺陷发生率呈逐年上升的趋势,且农村高于城市,男性高于女性。

Objectives To analyze types of birth defects and correlation factors in Nanhai to understand birth defects change tendency and to discuss intervention measures.Methods Perinatal birth over 28 weeks pregnancy and 7 days after the birth in two municipal hospitals were conducted birth defects surveillance from October 1,2002～September 30,2006 . The incidence of birth defects,category,constitution and correlation factors were analyzed. Results 21 593 cases of perinatal birth were born in 2003～2006,including the birth defect 407 cases,the incidence of birth defects increasing year by year. In 407 cases of birth defects,369 cases of single malformations,38 cases of multiple malformations. Birth defects were top 5 malformation: multi-finger (toe),congenital heart disease,total cleft lip and palate,hypospadias,and means (toe);Birth defect's formation rate countryside was higher than the city obviously (χ2 = 22.25,P<0 001); birth defects showed that the gender distribution of males than females,with significant difference test (χ2=13.88,P<0 01). Conclusions The incidence of birth defects assumes the tendency which rises year by year,and the countryside is higher than the city,the male is higher than the female.