P(NIPA-co-NVP)温敏凝胶微粒的相变性能与药物释放

Phase transition behaviour and drug releasing of thermo-sensitive micro-spheres of poly(N-isopropylacrylamide-co-N-vinyl-2-pyrrolidone) hydrogel

采用N-异丙基丙烯酰胺(NIPA)与N-乙烯基吡咯烷酮(NVP),以N,N-亚甲基双丙烯酰胺(MBA)为交联剂,氧化-还原试剂引发,通过反相悬浮共聚制备热缩温敏水凝胶微粒;研究了共聚单体配比及交联剂用量对凝胶温敏性能和溶胀性能的影响,并利用其温敏性以水杨酸为模型药物进行了药物吸附-释放实验。实验发现:NVP单体的加入使共聚凝胶的体积相变温度和平衡溶胀率都明显升高,药物吸附率增加,而溶胀-退溶胀的响应速度及水保留率降低,释药率降低。

N-isopropylacrylamide(NIPA) and N-vinyl-2pyrrolidone(NVP) were copolymerized with N,N-methyl biacrylamide(MBA) as the crosslinking agent and peroxides as the initiator,and thermo-sensitive micro-spheres of hydrogels were obtained through an inverse suspension polymerization.The effects of co-monomers ratio and amount of crosslinking agent on the sensitivity and swelling property of the gels were investigated,and the drug adsorption/releasing ability of the gels were determined with salicylic acid as the model drug.The degradability of the gels was also surveyed.The results show that the copolymerization of NIPA with NVP results in the increase of LCST,swelling ratio and drug adsorption of the gels,while the swelling/deswelling,and the drug releasing ratio decrease.