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LC-MS检测艾滋病常用药物浓度的研究进展 被引量：3

Research Advances of AIDs Medicines Determination by LC-MS
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摘要 对临床常用的抗艾滋病病毒药物(拉米夫定、齐多夫定、奈韦拉平、依非韦仑、司他夫定和克力芝)的理化性质,LC-MS测定生物样本药物浓度方法,药动学参数进行总结归类,以指导临床药物浓度监测和科研发展。 The physical and chemical characters,pharmacokinetics of anti-HIV virus medicines(lamivudine,stavudine,zidovudine,efivirenz,nevirapine and lopinavir/ritonavir)and methods used in determining these five medicines by LC-MS have been reviewed.This work can offer some help to treatment drug monitoring(TDM)and anti-HIV medicine research.
作者 张丽军 姚亚敏 孙建军 卢洪洲
机构地区 上海市公共卫生临床中心
出处 《中国现代应用药学》 CAS CSCD 北大核心 2009年第S1期1112-1115,共4页 Chinese Journal of Modern Applied Pharmacy
基金 卫生部课题(WA-2007-04)
关键词 抗病毒药物 艾滋病 液相色谱串联质谱 药动学 anti-virus medicine AIDs LC-MS pharmacokinetics
分类号 R96 [医药卫生—药理学]
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参考文献16

  • 1MISTRI H N,,JANGID A G,PUDAGE A,et al.High throughput LC-MS/MS method for simultaneous quantification of lamivudine,stavudine and nevirapine in human plasma. Journal of Chromatography B . 2007
  • 2ALNOUTI Y,LEWIS SR,WHITE C A,et al.Simultaneous determination of zidovudine and lamivudine from rat tissues by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry . 2005
  • 3ROBBINS B L,POSTON P A,NEAL E F,et al.Simultaneous measurement of intracellular triphosphate metabolites of zidovudine,lamivudine and abacavir(carbovir)in human peripheral blood mononuclear cells by combined anion exchangesolid phase extraction and LC-MS/MS. Journal of Chromatography B . 2007
  • 4COMPAIN S,DURAND-GASSELIN L,GRASSI J,et al.Improved method to quantify intracellular zidovudine mono-and triphosphate in peripheral blood mononuclear cells by liquid chromatography-tandemmass spectrometry. Journal of Mass Spectrometry . 2007
  • 5LIU Z,FAN-HAVARD P,XIE Z,et al.A liquid chromatography/atmospheric pressure ionization tandem mass spectrometry quantitation method for nevirapine and its two oxidative metabolites,2-hydroxynevirapine and nevirapine4-carboxylic acid,and pharmacokinetics in baboons. Rapid Communications in Mass Spectrometry . 2007
  • 6ROUZES A,BERTHOIN K,XUEREB F,et al.Simultaneous determination of the antiretroviral agents:amprenavir,lopinavir,ritonavir,saquinavir and efavirenz in human peripheral blood mononuclear cells by high-performance liquid chromatography-mass spectrometry. Journal of Chromatography B . 2004
  • 7JUNG B H,REZK N L,BRIDGES A S,et al.Simultaneous determination of17antiretroviral drugs in human plasma for quantitative analysis with liquid chromatography-tandem mass spectrometry. Biomedical Chromatography . 2007
  • 8DIFRANCESCO R,DICENZO R,VICENTE G,et al.Determination of lopinavir cerebral spinal fluid and plasma ultrafiltrate concentrations by liquid chromatography coupled to tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis . 2007
  • 9SLISH JC,CATANZARO LM,MA Q,et al.Update on the pharmacokinetic aspects of antiretroviral agents:implications in therapeutic drug monitoring. Current Pharmaceutical Design . 2006
  • 10Donnerer J,Kronawetter M,Kapper A,et al.Therapeutic Drug Monitoring of the HIV/AIDS Drugs Abacavir, Zidovudine, Efavirenz, Nevirapine, Indinavir, Lopinavir, and Nelfinavir. Pharmacology . 2003

同被引文献25

引证文献3

二级引证文献10

中国现代应用药学
2009年 第S1期

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