L-5-(2-乙酰氧基-丙酰胺基)-2,4,6-三碘异酞酰氯的合成

Synthesis of L-5-(2-acetoxy-propionylamino)-2,4,6-triiodoisophthaloyl dichloride

目的合成标题化合物,并进行改进。方法以5-氨基-2,4,6-三碘异酞酸为原料经酰氯化、酰胺化反应制得目标化合物。结果总收率达95.4%,目标化合物的结构经红外光谱和元素分析确证。结论改进的路线操作简便,易于控制,缩短了反应时间,降低了生产成本,更易于工业化生产。

OBJECTIVE To synthesize the title compound and improve the process.METHODS The title compound was synthesized from 5-amino-2,4,-6-triiodoisophthalic acid by acyl chlorination and amidation.RESULTS The overall yield was 95.4%,the title compound was characterized by IR and elemental analysis.CONCLUSION This synthetic technique is simple,economical and suitable for industrial manufacture.