轻度认知障碍的脑血流灌注显像的统计参数图分析

Statistical parametric mapping analysis of cerebral blood perfusion imaging in mild cognitive impairment

目的比较轻度认知障碍(MCI)患者和正常对照组脑血流灌注的差异,以探讨SPECT脑血流灌注显像在MCI临床诊断中的价值。方法MCI患者组及健康对照组各20例行SPECT脑血流灌注显像,并用SPM5b软件对图像进行处理,以体素为单位比较两组脑血流灌注水平的差异。结果与正常老龄化对照组相比,MCI患者组脑血流灌注相对降低区不对称分布在后扣带回、额上回、额下回、顶上小叶和顶下小叶。结论MCI患者SPECT脑血流灌注的改变具有一定的特征性,可以期待其在MCI临床诊断方面的应用前景。

Objective To investigate the characteristics of cerebral blood perfusion in the patients with mild cognitive impairment(MCI)by comparing to normal controls and to evaluate the potential roles of SPECT in identifying subjects with MCI from normal aging.Methods Twenty patients,who were diagnosed as having MCI,and 20 normal aging subjects each underwent a 99mTc-ethylcysteinate dime SPECT cerebral blood perfusion imaging.SPECT images were processed with SPM5b software and performed a voxel-based statistical analysis comparing MCI patients and normal aging subjects.Results In comparison with normal controls,subjects with MCI showed asymmetry hypoperfusion in the posterior cingulate gyrus,inferior and superior parietal lobule,cingulate gyrus,inferior and superior frontal gyrus.Conclusion Hypoperfusion is detected in reletively specific region in the patients with MCI and the clinical use of cerebral blood perfusion imaging for the detection of MCI is promising.