CK胶囊SD大鼠长期毒性试验病理学研究

A histopathologic study of CK capsule in SD rats within a repeated rose toxicological experiment

SD大鼠分为7.31,21.94,43.87g/kg3个剂量组,连续60d灌服CK胶囊原生药.给药60d及停药后15d大鼠的各主要器官进行病理学检查.结果显示CK胶囊原生药中剂量组1例雌性大鼠发现乳腺管状腺瘤.其余雌性动物乳腺均未见任何病理形态学改变.溶媒对照组、高剂量组动物的胃肠、脾脏、睾丸、卵巢等大部分脏器未见病理形态学改变.其中心脏、肝脏、肾脏、气管及胸腺可见不同程度的病理形态学改变.连续60d灌服43.87g/kgCK胶囊原生药的SD大鼠组织未观察到与受试药物有关的病理形态学改变.

To investigate the potential toxicity of CK capsule by histopathologic study in a repeated dose toxicological experiment in SD rats.SD rats were random divided into CK capsule 7.31,21.94,43.87g/kg groups.All animals were intragastric exposed for 60 consecutive days.Capital tissue and organ of rats underwent pathological examination separately after all animals were administrated 60 days and a recovery period for 15 days.One female rat in CK capsule median dosage group found breast tubular adenoma and there were not evidential found in the rest rats.The organs such as stomach intestine,spleen,testiculus and ovaries didn't find histopathologic changes.Other organs such as heart,liver,kidney,airtube and thymus observed different degrees histopathologic changes.No evidential histopathologic change induced by CK capsule were found in rat tissues which had been intragastric given 43.87g/kg CK capsule for 60 consecutive days.