中毒性表皮坏死松解症静脉免疫球蛋白治疗现状

Toxic epidermal necrolysis:a review of current treatment with intravenous immunoglobulin

中毒性表皮坏死松解症(TEN)是一种以迅速广泛的表皮松解剥脱为主要特征的少见而危重的药物皮肤不良反应。目前,该病尚无公认的特异性疗法。静脉免疫球蛋白(IVIG)作为一种颇有前途的新疗法,虽然在有效性及安全性方面尚存争议,但为临床医师提供了较开阔的思路和多样化的选择,有望降低该病病死率。本文将就中毒性表皮坏死松解症的静脉免疫球蛋白治疗现状进行一综述。

Toxic epidermal necrolysis(TEN)is considered to be a rare but potentially fatal adverse cutaneous drug reaction with rapid and extensive skin detachment.Currently,there are no specific treatments have been accepted.intravenous immunoglobulin(IVIG),Considered by many clinicians,has been proposed as a promising new therapy which is expected to reduce the mortality of TEN,although the efficacy and safety are still to be evaluated.This article reviews current data concerning IVIG treatment of TEN.