丹参酮在腹膜透析中对间皮细胞的影响

The Study of Mesothelial Cells on Tanshinone in Peritoneal Dialysis

目的:分析在腹膜透析过程中,研究丹参酮对间皮细胞增殖活性、氧化应激、转移生长因子(TGFβ1)分泌等所产生的影响,为以后的医学工作提供可靠地经验和依据。方法:收录110例进行腹膜透析的患者资料,将患者分为腹膜透析液(PDS)组和丹参酮两组,然后通过检测试验的方法,分析两组患者间皮细胞的增殖活性,对上清MDA、SOD、GSH水平,TGFβ1含量进行研究。观察GSH、SOD、MDA三者含量的变化情况。结果:在腹膜透析中,丹参酮可以对间皮细胞产生有关的作用,影响着间皮细胞的GSH,SOD,MDA等各项指标。结论:丹参酮除了对腹膜间皮细胞增殖活性的起到抑制作用,也可抑制氧化应激和TGFβ1分泌。

Objective: To analyze the process of peritoneal dialysis in the study of tanshinone on mesothelial cell proliferation,oxidative stress,transforming growth factor(TGF β1) secretion and so the impact for the future of medical work experience and based on reliable.Methods: 110 cases included information on patients with peritoneal dialysis,patients were divided into peritoneal dialysis solution(PDS) group and tanshinone two groups,and then by detecting the test methodology,analysis between the two groups of patients with skin cell proliferation activity of the supernatant of MDA,SOD,GSH level,TGF β1 content of research.Observation of GSH,SOD,MDA contents of three changes.Results: In peritoneal dialysis,the tanshinone mesothelial cells can be related to the role,affecting the mesothelial cells of GSH,SOD,MDA and other indicators.Conclusion: Tan in addition to peritoneal mesothelial cells play an inhibitory activity,also inhibit oxidative stress and TGF β1 secretion.