摘要
目的:观察羟丁酸钠对3类麻醉药镇痛作用的影响。方法:实验小鼠分为3大组(阿片组、吸入麻醉药组和解热镇痛药组)。第1大组共72只小鼠,分为3中组(芬太尼组、瑞芬太尼组、布托啡诺组),每中组各24只小鼠均随机分3小组(n=8);第2、3大组各30只小鼠,每大组均分为3小组(n=10)。用热板法观察羟丁酸钠对3类药的热板痛阈(HPPT)影响。结果:在不同实验中,与基础痛阈相比,各羟丁酸钠和生理盐水合用组在不同时间点的HPPT,均有一定程度的增高;与各生理盐水和麻醉药合用组相比,各羟丁酸钠和麻醉药合用组在不同时间点的HPPT均增高(P<0.05或P<0.01)。结论:羟丁酸钠有一定镇痛作用,且能够增强3类麻醉药的镇痛作用。
Objective:To observe the effect of sodium oxybate on analgesia of three types of anesthetics.Methods:Kunming Jimpy mice were divided into 3 big groups.There were 72 mice in the first big group which could be divided into 3 mid-groups of the same number.Then,the mid-groups were casually divided into 3 small groups which had 8 mice respectively.There were respectively 30 mice in the second big group and the third one.Each group was divided into 3 small groups of the same number.Pain threshold in hot-plate test(HPPT) was observed.Results:In different tests,the HPPT in each combined group of sodium oxybate and normal saline at different time points increased to some extent when comparing with basic HPPT.The HPPT in each group which combined sodium oxybate with the three types of anesthetics respectively at different time points increased when comparing with the groups which combined normal saline with the anesthetics respectively(P<0.05 or P<0.01).Conclusions:Sodium oxybate have the analgesic effect,and can also enhance the analgesic effect of three types of anesthetics.
出处
《航空航天医学杂志》
2009年第11期4-6,共3页
Journal of Aerospace medicine
基金
国家自然科学基金资助项目(30872432
30471657
39970715)
江苏省自然科学基金资助项目(BK200143)
2007年江苏省高等学校大学生实践创新训练计划项目(396
404)
关键词
羟丁酸钠
阿片类药
吸入麻醉药
解热镇痛药
镇痛
联合用药
Sodium oxybate
Opioid anesthetics
Inhaled anesthetics
Antipyretic analgesic drug category
Analgesia
Drug combination