DOC2和rasp21在大肠癌组织中的表达及其临床意义

Expression and significance of DOC2 and rasp21 in colorectal carcinoma tissue

目的研究DOC2和rasp21在大肠癌组织中的表达及其临床意义。方法选取未经过术前放化疗的大肠癌标本121例及癌旁正常黏膜组织44例,通过免疫组织化学SP法检测两组DOC2和rasp21蛋白的表达情况,分析两者的表达与大肠癌临床病理特征的关系及两者间的相互联系。结果大肠癌组织DOC2蛋白阳性表达率低于癌旁正常黏膜组织,rasp21蛋白阳性表达率高于癌旁正常黏膜组织(P<0.01)。DOC2蛋白的表达与大肠癌淋巴结及肝转移相关(P<0.05),rasp21蛋白的表达与大肠癌分化程度、淋巴结及肝转移相关(P<0.05)。大肠癌组织中DOC2与rasp21蛋白的表达呈负相关(r=-0.410,P<0.01)。结论DOC2和rasp21的表达失调可能在大肠癌的发生发展过程中发挥重要作用。

Objective To investigate the expression and clinical significance of DOC2 and rasp21 proteins in colorectal carcinoma.Methods The expression of DOC2 and rasp21 was detected by SP immunohistochemistry in samples including 121 cases of colorectal carcinoma tissues without radiotherapy or chemotherapy and 44 cases of para-carcinoma normal mucosa tissues.The correlation of DOC2 expression to rasp21 expression,and their correlations to the clinicophathologic features of colorectal carcinoma were analyzed.Results The expression of DOC2 of colorectal carcinoma was lower than that in para-carcinoma normal mucosa tissues.The expression of rasp21 of colorectal carcinoma was higher than that in para-carcinoma normal mucosa tissues.The expression level of DOC2 was significantly correlated with lymph node and liver metastasis.The expression of rasp21 was correlated with differentiated degree,lymph node and liver metastasis.There was a negative correlation between the expression of DOC2 and rasp21 in colorectal carcinoma(r=-0.410,P<0.01).Conclusion The imbalance of DOC2 and rasp21 expression may play a significant role in the occurrence and development of colorectal carcinoma.