期刊文献+

DCF方案治疗晚期胃癌临床观察 被引量:1

下载PDF
导出
摘要 目的观察DCF方案治疗晚期胃癌的疗效及毒副反应。方法选取晚期胃癌患者45例,DCF方案为:多西他赛75 mg/m2静脉滴注第1天,顺铂75 mg/m2分2~3 d静脉滴注,5-氟尿嘧啶(5-Fu)500 mg/m2静脉滴注第1~5天。每21 d为1周期,所有患者至少接受4个周期治疗。结果完全缓解2例、部分缓解16例、稳定13例、进展14例,总有效率40.0%。临床获益31例(68.9%)。疾病无进展时间为(4.28±0.31)个月,生存期为(9.03±0.55)个月。主要毒副反应为骨髓抑制、恶心、呕吐、脱发、肝肾功能损害。结论DCF方案治疗晚期胃癌疗效较好,毒副反应较常见,骨髓毒性较明显但可耐受。
出处 《山东医药》 CAS 北大核心 2009年第52期51-53,共3页 Shandong Medical Journal
  • 相关文献

参考文献6

  • 1K. Ridwelski,T. Gebauer,J. Fahlke,H. Kr?ning,E. Kettner,F. Meyer,K. Eichelmann,H. Lippert.Combination chemotherapy with docetaxel and cisplatin for locally advanced and metastatic gastric cancer[J]. Annals of Oncology . 2001 (1)
  • 2Ajani JA,Fodor MB,Tjulandin SA,et al.Phase Ⅱ multi-institutional randomized trial of docetaxel plus cisplatin with or without fluorouracil in patients with untreated, advanced gastric,or gastroesophageal adenocarcinoma. Journal of Clinical Oncology . 2005
  • 3Van Cutsem E,Moiseyenko VM,Tjulandin S,et al.Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group. Journal of Clinical Oncology . 2006
  • 4Mavroudis D,,Kourousis C,Androulakis N,et al.Front-line treatment of advanced gastric cancer with docetaxel and granulocyte colony-stimulating factor(G-CSF).A phase II trial. American Journal of Clinical Oncology . 2000
  • 5Thuss-Patience,PC,Kretzschmar,A,Repp,M,Kingreen,D,Hennesser,D,Micheel,S.Docetaxel and continuous-infusion fluorouracil versus epirubicin, cisplatin, and fluorouracil for advanced gastric adenocarcinoma: a randomized phase II study. Journal of Clinical Oncology . 2005
  • 6ROTH A D,AJANI J.Decetaxel-based chemotherapy in thetreatment of gastric cancer. Annals of Oncology . 2003

同被引文献7

引证文献1

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部