子宫内膜透明细胞癌的临床分析

Clinical Analysis of Endometrial Clear Cell Carcinoma

目的探讨子宫内膜透明细胞癌的临床特点、治疗及预后。方法回顾性分析580例子宫内膜癌患者中9例子宫内膜透明细胞癌患者的临床病理资料。结果9例患者确诊为子宫内膜透明细胞癌的平均年龄为59岁。术前诊刮的准确率为44.4%。9例患者均行手术治疗,术后补充放疗或化疗。随访7例,1例阴道断端复发,3例死亡,其余患者随访期内无复发或转移。结论子宫内膜透明细胞癌在子宫内膜癌的发病率较低,年龄较大,诊刮准确率低,预后差。治疗强调全面的分期手术,术后辅以铂类为主的化疗及腔内、体外放疗以改善其预后。

Objective To investigate the clinical characteristics,management and prognosis of endometrial clear cell carcinoma. Methods A total of 9 cases of endometrial clear cell carcinoma in the first affiliated hospital of China Medical University from January 1977 to January 2007 were analyzed retrospectively. Results The average age at the time of diagnosis was 59. The accurate rate of biopsy was 44.4%. All cases underwent surgery and had chemotherapy or radiation therapy after surgery. 1 case recurred at the vaginal cuff,3 cases died,and other cases survived after follow-up so far. Conclusion Endometrial clear cell carcinoma comprises a small percentage of endometrial cancers. The onset age is higher than that of endometrioid adenocarcinoma. It has been shown alow accurate rate of biopsy and poor prognosis. Patients with endometrial clear cell carcinoma should be treated with complete staging surgery and combined with chemotherapy or radiation therapy to improve their prognosis.