嗜酸性粒细胞阳离子蛋白在鼻部慢性炎症疾病中的分泌及意义

The secretion and use of eosinophil cationic protein from patients with chronic nasal disease

大量研究指出 :嗜酸性粒细胞阳离子蛋白 (ECP)是活化嗜酸性粒细胞 (EOS)检出的敏感标记 ,它在嗜酸性炎症 (如哮喘、变应性疾病等 )中扮演了重要角色。为了解ECP在鼻部常见慢性炎症 (鼻息肉、慢性鼻窦炎、变应性鼻炎 )中的表达和意义 ,作者查阅了与此有关的大量文献 ,结果发现ECP与这些疾病关系密切 ,检测鼻分泌物ECP浓度有助于对此类疾病的病情估计、转归和预后的判断。

Eosinophil cationic protein, a sensitive marker of activated eosinophils, plays an important role in eosinophila inflammation, such as asthma, allergy disease and so on. To get acknowledges of ECP of secretion and use in nasal general chronic disease(NP, CS and AR),we review many articles and summary the present situation of this topic of its properties and uses. We find a critical relationship between ECP and nasal general chronic disease. Moreover, the measurement concentration of ECP in nasal fluid can help evaluate degree, turnover and prognosis of these diseases.