The pharmacodynamics experiment of Xinkang injection protect action of ADR-induced toxin myocarditisin mice

Objective The experiment is to study the protective effects of Xinkang Injection on ADR-induced toxin myocarditisin mice.Methods The test of Xinkang Injection on ADR-induced toxin myocarditisin mice.Firstly,the animal of obnormal,weight and death rate.Secondly,the influnences of cardiogram of ADR-induced toxin myocarditisin mice.Thirdly,the influnences of lactate dehydrogenase(LDH),creatine kinase(CK)and glutamic oxaloacetic transaminasw(GOT)of ADR-induced toxin myocarditisin mice.Fouthly,the influnences of changes of cardioc pathological mechanism of ADR-induced toxin myocarditisin mice.Fifthly,the influnces of the caidioc ultrastructural of ADR-induced toxin myocarditisin mice.Results Firstly,to ADR-induced toxin myocarditisin mice,the weight of middle dose and high dose of Xinkang injection had declined obviosly which contrast with the constraction model mice team.In the mean time,the weight of Xinkang injection team had obviosly changde which contrast with contrastion mice team(P<0.01).Secondly,to ADR-induced toxin myocarditisin mice,the middle dose and high dose of Xinkang injection have obviosly withstand Q abnormal cardiogram,in the meantime,Xinkang injection team had obviosly changde contrast with the contrastion model mice(P<0.01).Thirdly,to ADR-induced toxin myocarditisin mice,The activity of lactate dehydrogenase(LDH),creatine kinase(CK)and glutamic oxaloacetic transaminasw(GOT)were differently measured.The middle dose and high dose of Xinkang injection team can obviously declined the activity of LDH and CK(P<0.01).Fouthly,to ADR-induced toxin myocarditisin mice,the low dose,the middle dose and high dose of Xinkang injection team can contrast with injured on toxic myocarditisin mice cardioc.Fifthly,to ADR-induced toxin myocarditisin mice,the low dose,the middle dose and high dose of Xinkang injection team have effect of allevite the injection of the cardioc ulteasteuctural of ADR-induced toxin myocarditisin mice.Conclusions Xinkang injection can protect the ADR-induced toxin myocarditisin mice.