重组改构肿瘤坏死因子联合顺铂治疗恶性胸腹腔积液分析

Analysis of cisplatin combined with tumor necrosis factor in treating malignant pleural effusion and ascites

目的研究重组改构肿瘤坏死因子联合顺铂腔内注入治疗恶性胸腹腔积液的疗效和不良反应。方法30例中至大量胸腹腔积液患者尽量排尽积液后,注入rmhTNF1000万IU或1600万IU,同时注入顺铂(DDP60-80mg/m)2,每周1次,共2-4次。结果30例病例中CR者8例,PR者18例,NC者4例,总有效率(CR+PR)为86.66%。生活质量提高并完成治疗者28例,另2例下降。结论rmhTNF局部治疗恶性胸腹腔积液疗效可靠,生活质量提高,无明显毒副作用,是治疗恶性胸腹腔积液的有效手段之一。

Objective To evaluate the efficacy and toxicity of rmhTNF in treating malignant pleural effusion and ascites.Methods 30 patients with malignant thoracic effusion were observed,rmhTNF 10 million U or 16 million U and cisplatin(DDP 60-80 mg/m2)were injected intraplurally after complete drainage,one times a week,until the malignant effusion and ascites no longer appeared,orall 2-4 times.Results Among 30 cases with malignant thoracic effusion,8,18 and 4 cases were CR,PR and NC respectively,the overall effective ratio was 86.66%.Conclusion rmhTNF inoculation is a good choice for patients with malignant thoracic effusion,which can improve patients,life quality significantly,and no obvious noxious and side effects were found,It is suitable for treating patients with malignant thoracic effusion who cannot bear chemotherapy.