615例小涎腺上皮性肿瘤的临床病理分析

A Retrospective Study on 615 Cases of Minor Salivary Gland Tumors

目的 探讨小涎腺上皮性肿瘤的临床病理特点。方法 对 6 15例小涎腺上皮性肿瘤的部位分布、发病年龄、性别及组织学类型进行回顾性分析。结果 6 15例小涎腺上皮性肿瘤中腺瘤 2 6 5例 ,癌 35 0例 ,良恶性肿瘤之比为 1∶1 3。良性肿瘤中以多形性腺瘤最为常见 (81 1% ) ,其次为肌上皮瘤 (14 7% )。恶性肿瘤中以腺样囊性癌最常见 (32 9% ) ,其次为粘液表皮样癌 (2 1 4 % ) ,腺癌 (11 7% )。小涎腺上皮性肿瘤以腭部最为好发 ,分别占良、恶性肿瘤的 77 0 %和 6 0 .0 %。腺瘤中女性患者 (5 1 3% )稍多于男性 (4 8 7% ) ;小涎腺癌患者中男性 (5 6 3% )多于女性(4 3 7% )。小涎腺腺瘤患者平均发病年龄 4 0 9岁 ,小涎腺癌平均发病年龄 4 9 1岁 ,恶性肿瘤的发病年龄显著高于良性肿瘤 (P <0 0 5 )。结论 小涎腺上皮性肿瘤在病理类型构成比、部位、年龄、性别分布上具有其独到的特点。

Objective To analyse the clinical and pathological characterstics of minor salivary gland tumors.Methods A retrospective analysis on 615 cases of intraoral minor salivary gland tumors from 1990～2002 with a confirmed pathologic diagnosis was carried out.Results In 615 cases of minor salivary gland tumors, 265 cases were benign, 350 cases malignant. Pleomorphic adenoma was the most common entity and accounted for 81.1%of all benign tumors. Adenoid cystic carcinoma comprised 32.9% of the malignant sample and was the most frequent malignant tumor. The principal location was the palate. Female was a little more of the benign and a male prevalence was observed on the malignant tumor. The mean age of patients with benign and malignant tumors were 40.9 and 49.1 years old, respectively (P<0.05).Conclusion We consider extraordinary manifestation as histopathology, tumor, primary location, age and sex, presenting the results of a review of our experience with those minor salivary gland tumors.