两种钛种植体与骨结合界面的组织学研究

The Morphological Study of Bone-implant Interfaces in vivo

目的 对两种表面形态不同的钛种植体在不同种植时期骨结合界面情况进行研究。方法 在恒河猴下颌磨牙区分期分别植入CDIC和ITI_TPS钛种植体 ,采用同体对照的方法 ,对两种种植体与骨结合界面情况进行组织学观察。结果 口腔检查未见种植体松动及周围组织明显炎症表现。各期种植体骨界面X线影像均未见明显透射暗影 ,仅种植 1个月的CDIC种植体颈部见少量角形吸收。光镜和扫描电镜观察见种植 1个月后两种种植体骨界面有少量骨形成 ;1～ 3个月ITI_TPS种植体界面骨形成较明显 ,成骨量统计分析 ,差异有显著性 ;种植后 1年 ,两者未见明显差别。结论 无载荷条件下 ,种植体植入后 1～ 3个月内 ,ITI_TPS种植体表面骨结合形成优于CDIC种植体。随植入时间的增加 ,两种种植体均形成良好的骨性结合界面。

Objective To evaluate the bone-implant interfaces of two kinds of implants with different surfaces in different time in vivo.Methods CDIC and ITI-TPS solid-screw cylinder pure titanium implants were selected and implanted in the regions of posterior molars of rhesus monkeys. 1 month, 2 months, 3 months and 1 year after surgery, the bone-implant interfaces were evaluated respectively through oral examination, X-ray inspection, light microscope and scanning electron microscope (SEM) observation.Results None of the implants was loose. Soft tissue around implants appeared no inflammation. There were no apparent transparent shadow around the implants interfaces in X-ray photos except little angle-shaped absorption was showed in neck region of CDIC implants of one-month. New bone was observed around implants of one-month through light microscope and SEM. More bone growing around ITI implants were seen than that around CDIC implants except the interfaces of one-year.Conclusion The osseointegration of ITI implants are better than that of CDIC implants during three months after implanting without loading, The bone formation at the interfaces of ITI and CDIC implants has no significant difference after one year without loading.