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THE STUDY ON RELATION BETWEEN CD1a^+ CELLS AND INFILTRATIVE CD3 ^+ AND CD8 ~ + CELLS IN RENAL TISSUE OF GLOMERULONEPHRITIS

THE STUDY ON RELATION BETWEEN CD1a^+ CELLS AND INFILTRATIVE CD3 ^+ AND CD8 ~ + CELLS IN RENAL TISSUE OF GLOMERULONEPHRITIS
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摘要 Objective To discuss the role of dendritic cell s (DCs) in cellular immunity pathogenesis of glomerulonephritis (GN). Meth ods 114 patients with GN were selected randomly and divided into two gr oups, primary GN (pGN) and secondry GN (sGN). CD1a +, CD3 + and CD8 + cells in bioptic renal tissues were examined immunohistochemically. The di stribution of CD1a + cells and the infiltration of CD3 + and CD8 + cells in renal tissues were observed. Results There was no si gnificant difference of CD1a +, CD3 +, and CD8 + cells between pG N and sGN group (P>0.05). CD1a + cells had significant positive correla tion with the infiltrative CD3 + and CD8 + cells, respectively (P< 0.01). The infiltrative CD3 + cells had significant positive correlation wi th the CD8 + cells in the same area, respectively (P<0.01). CD1a + cells, CD3 + cells infiltrating in both glomeruli and renal interstitial t issues, and CD8 + cells only infiltrating in renal interstitial tissues, al l of them had significant positive correlation with the degree of glomerular pro liferation, respectively (P<0.05). The infiltrative CD3 + and CD8 + cells in renal interstitial tissues had significant positive correlation with the degree of glomerular sclerosis and the lesion degree of renal tubule and in terstitial, respectively (P<0.05). There were significant positive correlati on between CD1a + cells and the lesion degree of renal interstitial (P< 0.05). Conclusion DCs could activate T lymphocyte by presenting antigen, then the activated T lymphocyte participate in the pathogenesis of GN through releasing cytokine and/or directly damaging the renal tubule and interst itial, which produce more serious glomerular lesion. Objective To discuss the role of dendritic cell s (DCs) in cellular immunity pathogenesis of glomerulonephritis (GN). Meth ods 114 patients with GN were selected randomly and divided into two gr oups, primary GN (pGN) and secondry GN (sGN). CD1a +, CD3 + and CD8 + cells in bioptic renal tissues were examined immunohistochemically. The di stribution of CD1a + cells and the infiltration of CD3 + and CD8 + cells in renal tissues were observed. Results There was no si gnificant difference of CD1a +, CD3 +, and CD8 + cells between pG N and sGN group (P>0.05). CD1a + cells had significant positive correla tion with the infiltrative CD3 + and CD8 + cells, respectively (P< 0.01). The infiltrative CD3 + cells had significant positive correlation wi th the CD8 + cells in the same area, respectively (P<0.01). CD1a + cells, CD3 + cells infiltrating in both glomeruli and renal interstitial t issues, and CD8 + cells only infiltrating in renal interstitial tissues, al l of them had significant positive correlation with the degree of glomerular pro liferation, respectively (P<0.05). The infiltrative CD3 + and CD8 + cells in renal interstitial tissues had significant positive correlation with the degree of glomerular sclerosis and the lesion degree of renal tubule and in terstitial, respectively (P<0.05). There were significant positive correlati on between CD1a + cells and the lesion degree of renal interstitial (P< 0.05). Conclusion DCs could activate T lymphocyte by presenting antigen, then the activated T lymphocyte participate in the pathogenesis of GN through releasing cytokine and/or directly damaging the renal tubule and interst itial, which produce more serious glomerular lesion.
出处 《Journal of Pharmaceutical Analysis》 SCIE CAS 2004年第2期148-151,163,共5页 药物分析学报(英文版)
基金 ThisworkwassupportedbytheNaturalScienceFoundationofShaanxiProvince,China(No.2000SM48).
关键词 GLOMERULONEPHRITIS dendritic cells cellular imm unity glomerulonephritis dendritic cells cellular imm unity
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