外周血血内皮抑素含量检测在原发性肺癌诊治中的意义

The Study on the Change of Serum Endostatin levels in the Patients with Primary Lung Cancer

目的 研究原发性肺癌患者外周血内皮抑素的含量水平与肺癌临床病理因素的关系。方法:用ELISA法对79例原发性肺癌、8例肺部良性疾病及20例健康人血浆内皮抑素含量进行分析。结果:血浆内皮抑素含量在79例原发性肺癌、8例肺部良性疾病及20例健康人分别为(9.3±5.7)pg/mL、(6.3±2.5)pg/mL、(4.9±3.2)pg/mL,肺癌明显高于肺部良性疾病和健康人有显著差异性(p<0.05);血浆内皮抑素含量在Ⅰ、Ⅱ、Ⅲ、Ⅳ期肺癌中分别为(6.6±4.3)pg/mL、(7.1±5.5)pg/mL、(8.7±6.0)pg/mL、(10.6±4.5)pg/mL,血浆内皮抑素含量与肺癌临床分期有关(p<0.05):年龄≥60岁肺癌患者血浆内皮抑素含量为(7.9±4.2)pg/mL,年龄<60岁肺癌患者血浆内皮抑素含量为(10.4±5.6)pg/mL,后者明显高于前者,二者比较差异有显著性(p<0.01)。术前血浆endostalin含量为(9.3±5.7)pg/mL,而术后为(8.2±6.2)pg/mL,二者存在显著差异(p<0.05)。结论:原发性肺癌患者外周血内皮抑素含量水平显著高于正常对照且与肿瘤分期、淋巴结转移有关,而术后其含量明显降低,这可能为肺癌手术后的动态观察(复发、转移)提供新的指标。

Objective: To elevate the clinical usefulness of serum endostatin levels in the patients with the operable lung cancer. Methods: Serum endostatin concentrations were measured by an enzyme linked immunocorbant assay in healthy controls and in 79 lung cancer patients before surgery. The association between serum endostatin levels and clinicopathological features was observed. Results: Serum endostatin levels in pulmonary carcinoma patients were significantly higher than those in controls. There was a significant association between serum endostatin levels and disease stage,and the presence of lymph node metastases. Conclusions: Serum endostatin levels in lung cancer patients are significantly higher compared with normal controls and correlate with disease stage and the presence of lymph node metastases. Elevated endostatin levels appear to be associated with tumor aggressiveness. The role of these cytokines in tumor angiogenesis and as potential targets for therapy warrants further study.