C反应蛋白含量对不稳定型心绞痛患者预后的影响

The Prognosis Value of C-reactive Protein in Unstable Angina

目的 为探讨炎症急性期标志物对不稳型性心绞痛的预后意义。方法 用散射比浊法测定了26例不稳定型心绞痛患者的C反应蛋白,并同时检测了肌酸磷酸激酶、心肌肌钙蛋白T。结果入院后第1日所有患者的肌酸磷酸激醇和心肌肌钙蛋白T水平均正常;61.5％患者的C反应蛋白≥5.0 mg/L,其中15例发生心绞痛,1例猝死,9例需冠脉再通。在10名C反应蛋白<5.0mg/L的患者中,未发生猝死及心肌梗塞,仅1名需冠脉再通。结论不稳定型心绞痛患者C反应蛋白升高,预后不良,并提示炎症是本病发病机制中的一个重要部分。

Objective To study the prognostic value of measurement of the circulating acute-phrase reactant C-reactive protein,which is sensitive indicators of inflammation. Methods We measured C-reactive protein in 26 patients with unstable angina pectors. Results At the time of hospital admission,the level of C-reactive protein was >5. 0mg/L in 16 patients with unstable angina pectors (62%) and more ischemic episodes than those with levels <5. 0mg/L(.P<0. 01), 1 died,and 9 required immediate coronary revascularization. No deaths or myocardiac infarction occurred among the 10 patients with levels of C-reactive protein <5. 0mg/L,and only 1 of them required coronary revascularization. Conclusions Elveation of C-reactive protein at the time of hospital admission predicts a poor outcome in patients with unstable angina pectors and may reflect an important inflammatory compoent in the pathogenesis of this confition.