藻酸双酯钠治疗糖尿病肾病32例临床分析

PSS in Treatment of Diabetic Nephropathy for 32 Simples

目的观察PSS对糖尿病肾病的治疗效果。方法64例糖尿病肾病患者随机分A、B两组。A组在常规治疗基础上用生理盐水250ml加PSS100mg静脉滴注,每天一次,14天一个疗程,B组予以常规治疗,用生理盐水250ml加丹参400mg静脉点滴,每天一次,14天一个疗程。结果 A组治疗后尿蛋白明显减少差异显著(P<0.01),而B组治疗前后尿蛋白变化无差异(P>0.05),A、B两组疗效比较差异显著。结论糖尿病肾病临床蛋白尿期,PSS治疗对减少尿蛋白有一定疗效。

Objective To study the effect of PSS on diabetic nephropathy(DN). Methods 64 cases of DN were divided into two groups(A,B). Patients in group A were treated with NaC10. 9% 250ml and subcutaneous PSS once daily for 14 days in addition to conventional therapy and those in group B were only given conventional therapy with NaCl 0. 9% 250ml and Danshen 400ml. Results Urinary protein reduced significantly (P<0. 01)in group A after therapy. In group B,there was no difference on urinary protein between pre-treatment and post-treatment(P>0. 05). The therapeutic effect was singnificantly different(P<0. 05)between group A and B. Conclusion PSS can reduce uriary protein on DN with clinical proteinuria.