他汀类调脂药的药理及临床
摘要
他汀类调脂药3-羟基-3甲基戊二酰辅酶A(HMG-CoA)还原酶抑制剂自问世以来,在临床上已广泛应用。该类药物具有调脂作用强,副作用小等优点,除调脂作用外,在冠心病的一级预防和二级预防中也发挥着重要作用,并且,研究表明,长期应用他汀类调脂药物可降低心血管病的发生率及死亡率。
出处
《青岛医药卫生》
2003年第4期292-293,共2页
Qingdao Medical Journal
参考文献13
-
1黄震华.新型调脂药物西立伐他汀[J].中国新药与临床杂志,2000,19(5):345-347. 被引量：13
-
2黄震华.新型降脂药物阿托伐他汀[J].中国新药与临床杂志,2000,19(1):54-56. 被引量：29
-
3陈庆华,魏经汉,沈玉祥,高传玉,崔天祥.国产与进口洛伐他汀治疗高脂血症的比较[J].中国新药与临床杂志,1999,18(5):270-272. 被引量：9
-
4毛昌朔,过鑫昌.普伐他汀的抗凝和纤溶功能对冠心病的影响[J].新药与临床,1997,16(4):221-222. 被引量：11
-
5王维治,徐凯建,高清芳,赵晓和,阎晓波.普伐他汀和烟酸肌醇脂治疗原发性高胆固醇血症的比较[J].新药与临床,1995,14(2):71-74. 被引量：7
-
6Hunninghake DB.Clinical efficacy of cerivastatin:phase II a doseranging and dose-scheduling studies. The American Journal of Cardiology . 1998
-
7Soma MR.Baetta R.Rita De Renzis M,et al.In vivo enhanced antitumor activity of carmustine[N, N-Bis (2-chlor-oethyl)-N-ni-trosourea]by simvastatin. Cancer Research . 1995
-
8Brown MS,Goldstein JL.A receptormediated pathway for cholesterol homeostasis. Science . 1986
-
9Foley DP,Bonnier H,Jackson G,et al.Prevention of restenosis after coronary balloon angioplasty: Rationale and design of the Fluvastatin Angioplasty Restenosis (FLARE) trial. The American Journal of Cardiology . 1994
-
10Sacks FM,pfefferMA,Moye LA.et al.The effect of pravas-tatin on coronary, events after myocardial infarction in partients with average cholesterol levels. The New England Journal of Medicine . 1996
二级参考文献18
-
1王维治,徐凯建,高清芳,赵晓和,阎晓波.普伐他汀和烟酸肌醇脂治疗原发性高胆固醇血症的比较[J].新药与临床,1995,14(2):71-74. 被引量：7
-
2迟家敏 孙美珍 等.美降脂治疗原发性高胆醇血症的临床观察[J].中华内科杂志,1992,31:32-4.
-
3[1]Plosker GL, Wagstaff AJ. Fluvastatin: a review of its pharmacology and use in the management of hypercholesterolaemia[J]. Drugs 1996; 51: 433-59.
-
4[2]Naoumova RP, Marais AD, Mountney J, et al. Plasma mevalonic acid, an index of cholesterol synthesis in vivo, and responsiveness to HMG-CoA reductase inhibitors in familial hypercholesterolaemia[J]. Atherosclerosis 1996; 119: 203-13.
-
5[3]Blum CB. Comparison of properties of four inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase[J]. Am J Cardiol 1994; 73 Suppl D: 3D-11D.
-
6[4]Bakker-Arkema RG, Davidson MH, Goldstein RJ, et al. Efficacy and safety of a new HMG-CoA reductase inhibitor, atorvastatin, in patients with hypertriglyceridemia[J]. JAMA 1996; 275: 128-33.
-
7[5]Haria M, McTavish D. Pravastatin: a reappraisal of its pharmacological properties and clinical effectiveness in the management of coronary heart disease[J]. Drugs 1997; 53: 299-336.
-
8[6]Bocan TMA, Mazur MJ, Mueller SB, et al. Antiatherosclerotic activity of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase in cholesterol-fed rabbits: a biochemical and morphological evaluation[J]. Atherosclerosis 1994; 111: 127-42.
-
9[7]Lea AP, McTavish D. Atorvastatin, a review of its pharmacology and therapeutic potential in the management of hyperlipidaemias[J]. Drugs 1997; 53: 828-47.
-
10[8]Heinonen TM, Stein E, Weiss SR, et al. The lipid-lowering effects of atorvastatin, a new HMG-CoA reductase inhibitor: results of a double-masked study[J]. Clin Ther 1996; 18: 853-63.
共引文献60
-
1孙云.他汀类药物的临床应用及不良反应[J].内蒙古医学院学报,2006,28(S1):240-241. 被引量：4
-
2徐明彤,薛声能,杨桂芳.阿托伐他汀治疗混合型高脂血症40例临床观察[J].新医学,2003,34(z1):20-21.
-
3刘歆,张新明.调脂药物的临床应用现状[J].青岛医药卫生,1999,31(1):54-55.
-
4王淑瑞,李玉,李慧.他汀类调脂药的发展现状、药学研究及临床应用[J].中国药事,2004,18(11):689-690. 被引量：4
-
5田卉,陈虹,马建慧.血脂异常的西医治疗新进展[J].农垦医学,2003,25(6):443-446.
-
6钟锦,陈原,熊维建.阿托伐他汀治疗儿童原发性肾病综合征高脂血症1例[J].儿科药学杂志,2005,11(1):50-51. 被引量：3
-
7倪桂芬.蛇口人民医院2002～2003年降血脂药物应用分析[J].中国误诊学杂志,2005,5(4):665-666. 被引量：1
-
8郁韵秋,黄建明,翁伟宇,顾丽华,王以俭,张莉.高效液相色谱-质谱联用法测定人血浆中洛伐他汀的浓度[J].中国新药与临床杂志,2005,24(12):954-957. 被引量：2
-
9丁月红.HMG-CoA还原酶抑制剂在调脂方面的临床应用[J].海峡药学,2006,18(5):157-158. 被引量：4
-
10吴云,梁戎,刘娟,赵兴胜.赖诺普利和卡托普利治疗高血压疗效观察[J].内蒙古医学杂志,2007,39(3):318-319.
-
1知名药师解答“三高”用药[J].首都医药,2010(19):58-58.
-
2陆勤燕.他汀类调脂药物临床应用进展[J].中国疗养医学,2002,11(4):32-33.
-
3赵俊英.前列地尔注射液治疗老年糖尿病肾病40例疗效分析[J].吉林医学,2011,32(32):6807-6808. 被引量：5
-
4侯中宁.低分子肝素联合硝酸甘油治疗不稳定型心绞痛41例疗效观察[J].中国伤残医学,2012,20(3):54-55.
-
5他汀类调脂药物可能有助抗癌[J].家庭用药,2012(11):7-7.
-
6杨玺.调脂药物的分类[J].中国社区医师,2009,25(23):6-6.
-
7杨玺.调脂药物的分类[J].中国社区医师（医学专业）,2010,12(25):4-4.
-
8茆华武.加用他汀类调脂药物治疗急性脑梗死的疗效观察[J].中国医药导刊,2010,12(10):1736-1737. 被引量：6
-
9陈灏珠.他汀类调脂药物[J].中国处方药,2004(6):10-14. 被引量：10
-
10张家庆.新一代调脂药“亮剑”[J].家庭用药,2015,0(11):26-27.
