围手术期输血对非小细胞肺癌患者术后无病生存的影响

Influence of perioperative blood transfusion on disease-free survival in non-small cell lung cancer patients

目的 :研究围手术期输注异体全血或红细胞对非小细胞肺癌术后无病生存时间的影响 .方法 :回顾性调查了 70例接受了手术治疗的非小细胞肺癌患者 ,其中 5 3例 (75 .7% )患者接受了围术期输全血或红细胞悬液 .无病生存期分析采用多因素Cox回归模型 ,并绘制生存曲线 .结果 :Cox模型因素分析表明 ,影响预后的主要因素 (P <0 .0 5 )有分化程度、术后分期、术后辅助治疗措施 ;而包括围手术期输血等均非主要预后因素 (P >0 .0 5 ) ;但生存曲线显示 ,围手术期输血具有缩短非小细胞肺癌患者无病生存期的趋势 .结论 :围术期输血可能具有缩短非小细胞肺癌患者无病生存时间的趋势 。

AIM: To study the influence of perioperative allogeneic blood transfusions on disease free survival in non small cell lung cancer patients treated with curative pulmonary resection. METHODS: Among the 70 patients with primary non small cell lung cancer, 53 (75.7%) received allogeneic blood products. Multivariate Cox regression model was used to analyze the disease free survival and to draw survival curves. RESULTS: In the multivariate analysis, differentiation, stage and post operation adjuvant treatment were found to be the significant factors affecting the prognosis ( P <0.05), whereas the blood transfusion and other factors were not significant ( P >0.05). The survival curves showed that perioperative allogeneic blood transfusions decreased the disease free survival in non small lung cancer patients ( P >0.05). CONCLUSION: Perioperative allogeneic blood transfusions may decrease the disease free survival in non small lung cancer patients. If possible, surgeons should avoid using perioperative allogeneic blood transfusion.