摘要
Objective To investigate the mechanism of tazarotene in active psoriasis vulgaris. Methods HB EGF protein in active psoriatic lesions before and 10 days after the treatment of tazarotene was detected by immunohistochemistry. Results There was nearly no expression of HB EGF in psoriatic lesions (9.1%), but after the treatment by tazarotene, there was expression of HB EGF not only in basal layer (95.5%), but also focal expression in suprabasal layers of epidermis (77.3%) . Conclusion Tazarotene inhibit proliferation and induce apoptosis of keratinocytes through upregulating expression of HB EGF in psoriatic epidermis.
Objective To investigate the mechanism of tazarotene in active psoriasis vulgaris. Methods HB EGF protein in active psoriatic lesions before and 10 days after the treatment of tazarotene was detected by immunohistochemistry. Results There was nearly no expression of HB EGF in psoriatic lesions (9.1%), but after the treatment by tazarotene, there was expression of HB EGF not only in basal layer (95.5%), but also focal expression in suprabasal layers of epidermis (77.3%) . Conclusion Tazarotene inhibit proliferation and induce apoptosis of keratinocytes through upregulating expression of HB EGF in psoriatic epidermis.
基金
ThisworkwassupportedbytheNationalNaturalScienceFoundationofChina (No .3 0 0 70 699)
