谷氨酰转肽酶、硷磷酶、亮氨酸氨基肽酶及其高分子酶测定在黄疸鉴别中的意义

SIGNIFICANCE IN DIFFERENTIATING JAUNDICE BY DETERMINATION OF GGT, AKP,LAP AND THEIR HIGH-MOL ECULAR-WEIGHT COMPLEXES

肝内、肝外胆汁郁积的鉴别诊断非常重要,因两者的病因不同,处理亦异。然而迄今尚无理想的能区别肝内、肝外胆汁郁积的生化指标。本文研究某些胆汁郁积标志酶及其同工酶,旨在从中筛选出一些对鉴别胆汁郁积有诊断价值的标记。材料和方法一、病例选择:正常组30例,肝胆病患者120例,其分组情况见表1。所有病例均按通用的诊断标准,由专人核实诊断。

Serum levels of GGT,AKP,LAP and their high-molecular-weight complexes H-CCT, H-AKP, H-LAP, Which were separated by the mini-column chromatography of Sephacryl S-300,were simultaneously determined in 120 patients with hepatobiliary diseases and 30 normal subjects. All the 6 markers and G-H/T were significantly higher in extrahepatic cholestasis (EHC),particularly in malignant EHC,than those in intrahepatic cholestasis and other liver diseases.The diagnostic specificity of these markers in malignant EHC may be greatly increased as the diagnostic criteria were raised properly Combined detection has better diagnostic sensitivity in EHC than detection of the markers alone.The markers were screened and the enzyme pattern of cholestasis was worked out.