闽东地区新生儿败血症54例分析

Clinical analysis of 54 cases with neonatal sepsis in the Mindong areas

目的 为了解闽东地区新生儿败血症临床表现、主要病原菌及其药敏情况。方法 本篇回顾性分析了54例2000年2月～2003年4月闽东医院儿科住院的血培养阳性的新生儿败血症患儿的临床表现、主要病原菌、药敏实验结果。结果主要临床表现:黄疸占48.1％,少哭、少动、少吃、反应差占46.3％,外周血象WBC<10 × 109/L占37.1％。金黄色葡萄球菌败血症26例(占48.1％)和表皮葡萄球菌16例(占29.6％)为主要致病菌。几乎全部对青霉素及红霉素耐药,对菌必治与先锋V敏感率>73.1％,尚未发现耐万古霉素的菌株。结论 新生儿出现黄疸、反应差等临床表现即使血白细胞不高也需考虑败血症的可能,治疗首选抗菌素为先锋V。

Objective:To comprehend the clinical manifestation,main pathogenic bacteria and drug- resistant of neonatal sepsis in the Min-dong areas. Methods: We analyzed 54 inpatients of neonatal sepsis in pediatric department of Mindong hospital from 2000.2 to 2003.4 with their clinical manifestation,main pathogenic bacteria and drug- resistant. Results:The main clinical manifestation are jaundice(48.1 %) and less - rejection(46.9% ) . The white blood cell(WBC) of peripheral hemogram less than 10 × 109/L take 37.1% . 26 cases of staphylococcus aureus (48.1%) and 16 cases of staphylococcus epidermis (29.6 % ) are the main pathogenic bacteria. Almost all of these are resistanted to penicillin and erythromycin. The sensitive rates to ceftriaxone and cephazoline are more than 73.1 % . Haven't finded the bacteria that is resis-lanled to vancomycin. Conclusion: Neonates have the clinical manifestation of jaundice or less- rejection shall consider of suffering from sepsis, even it's WBC is below 10 × 10 /L.We choose cephazoline for treatement first.