期刊文献+

对肾小球裂隙隔膜相关分子成分的研究进展 被引量:1

原文传递
导出
摘要 新近发现肾小球裂隙隔膜 (slitdiaphragm ,SD)相关成分对理解肾小球性蛋白尿的发生有重要的指导意义。有关Nephrin、与Podocin、CD2AP、actinn 4等分子结构及功能的研究取得了较大的进展 ,已基本阐明上述几种成分相互结合构成肾小球滤过屏障的主要成分 ,对高度特异性的足细胞功能发挥了关键作用 。
作者 余健 聂国明
出处 《国际泌尿系统杂志》 2003年第S1期70-72,共3页 International Journal of Urology and Nephrology
关键词 蛋白尿 肾小球
  • 相关文献

同被引文献19

  • 1Kestila M,Lenkkeri U,Mannikko M,et al.Positionally cloned gene for a novel glomerular protein-nephrin is mutated in congenital nephrotic syndrome.Mol Cell,1998,1:575-582
  • 2Tryggavasen K.Unraveling the mechanisms of glomerular ultrafiltration:nephrin,a key component of the slit diaphragm.J Am Soc Nephrol,1999,10:2440-2445.
  • 3Lenkkeri U,Mannikko M,McCready P,et al.Structure of the gene forcongenital nephrotic syndrome of the Finnish type(NPHS1) and characterization of mutations.Am J Hum Genet,1999,64:51-61.
  • 4Lahdenkari AT,Kestila M.Nephrin gene (NPHS1) in patients with minimal change nephrotic syndrome (MCNS).Kidney Int,2004,65:1856-1863.
  • 5Miller SA,Dykes DD,Polesky HF.A simple salting out procedure for extracting DNA from human nucleated cells.Nucleic Acids Res,1988,16:1215.
  • 6White RHR,Glasgow EF.Clinical pathological studies of nephrotic syndrome in childhood.Lancet,1970,1:1353.
  • 7Kaplan JM,Kim SH,North KN,et al.Mutations in ACTN4,encoding alpha-actinin-4,cause familial focal segmental glomerulosclerosis.Nat Genet,2000,24:251-256.
  • 8Tryggvason K,Wartiovaara J.Molecular basis of glomerular permselectivity.Curr Opin Nephrol Hypertens,2001,10:543-549.
  • 9Roselli S,Gribouval O,Boute N,et al.Podocin localizes in the kidney to the silt diaphragm area.Am J Pathol,2002,160:131-139.
  • 10Shih NY,Li J,Cotran R,et al.CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain.Am J Pathol,2001,159:2303-2308.

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部