AsAb与男性不育的相关性研究

Study of Correlation between AsAb and Male Infertility

目的观察不育男性血清、精浆中 AsAb 与精液各指标之间的关系,揭示 AsAb 与不育症的相关性及致病机制。方法 ELISA 法测定127例男性不育患者及86例正常生育者血清、精浆中的 AsAb 以及精液的各项指标。结果不育者血清中的 AsAb 阳性率(29.9%)明显高于正常生育组(4.7%),p<0.05,不育患者血清、精浆 AsAb 水平变化能导致精子的活动力明显下降,呈显著性正相关(p<0.05)。结论AsAb 与男性不育有密切关系,可引起精子活动力明显下降,但对精子密度及液化无明显影响。

Objective To examine the relationship between AsAb in sera and semen and other indexes of semen of male infertiltity,and to find out the correlation between AsAb and infertility and mechanism of infertility.Methods AsAb in sera and semen and other indexes of semen from 127 cases of male infertile patients and 86 normal persons were measured with ELISA.Results The positive rate of AsAb in the sera of in- fertile patients(29.9%)was significantly higher than that of normal controles(4.7%),P<0.05.The change of AsAb lev- el could cause a remarkable decrease of sperm activity.There was a significant positive correlation(P<0.05).Conclusion AsAb is closely related to male infertility,and may lead to a remarkable decrease of sperm activity,but does not signifi- cantly affect sperm density and liquidization.