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内皮素及其受体与妇科肿瘤 被引量:1

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摘要 内皮素(ET)不仅具有缩血管作用,同时也是一种有丝分裂原。其由肿瘤细胞通过自分泌和/或旁分泌方式释放后与受体结合,刺激细胞DNA的合成,促进细胞增殖,抑制细胞凋亡,诱导肿瘤血管形成。研究发现在女性生殖道存在ET及内皮素受体(ETR),并与妇科良性肿瘤的发生、发展及多种恶性肿瘤的形成、生长、浸润和转移有密切关系。
作者 李小叶 张怡
出处 《国外医学(妇产科学分册)》 2004年第3期185-187,共3页 Foreign Medical Sciences(Obstet Gynecol Fascicle)
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  • 1Uchide T,Masuda H,Mitsui Y,et al.Gene expression of vasoactive intestinal eontraetor/endothelin-2 in ovary,uterus and embryo:Comprehensive gene expression profiles of the endothelin ligand-reeeptor system revealed by semi-quatitatlve RT-PCR analysis in adult mouse tissues and during late embryonic development. J Mol Endocrinol,1999,22(2):161-171.
  • 2Bagnato A, Salani D, Castro Di V, et al.Expression of endothelin-1 and endothelin A receptor In ovarian carcinoma.Cancer Res, 1999,59(1):720-727.
  • 3Bagnato A, Rpsano L, Castro DV, et al. Endothelin receptor blockade inhibits proliferation of Kaposi's sarcoma cells.Am J Pathol, 2001,158(3):841-847.
  • 4Eberle J, Fecker LF, Orfanos CE, et al.Endothelin-1 decreases basic apoptotic rates in human melanoma cell lines.J Invest Dermatol,2002,119(3):549-555.
  • 5Ogata Y, Takahashi M, Ueno S, et al. Antiapoptotic effect of endothelin-1 in rat cardiomyocytes In vitro.Hypertension,2003,341(5): 1156-1163.
  • 6Grant K, Loizidou M, Taylor I, et al. Endothelin-l:a multifuntional molecule in cancer. Br J Cancer,2003,88(2): 163-166.
  • 7Salani D, Castro DV, Nicotra RM, et al. Role of endothelin-1 in nevascularization of ovarian carcinoma. Am J Pathol, 2000, 157(5): 1537-1547.
  • 8Bagnato A,Spinella F.Emering role of endothelin-1 in tumor angiogenesis.Trends Endocrinol Metab,2002,14(1 ):44-50.
  • 9Venuli A, Salani D, Cirilli A, et al. Endothelin receptor blockade inhibits the growth of hpapillomavirus-associated cervical carcinoma.Clin Sci, 2002,103 [ Suppl 48 ] :S310-313.
  • 10Bagnato A, Cirilli A, Salani D. ei al. Growth inhibition of cervix cells In vivo by endothelin A receptor blockade. Cancer Res, 2002, 62:6381-6384.

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