原发性中枢神经系统淋巴瘤的综合治疗附21例报告

The Synthetical Treatment of Primary Central Nervous System Lymphoma (review of 21 patients)

原发性中枢神经系统淋巴瘤临床较为少见,国内报告占中枢神经系统肿瘤的0.74%,近年发病率有上升趋势,该病术前诊断困难,治疗效果差。本文总结我院对原发性中枢神经系统淋巴瘤治疗的经验,旨在进一步提高对本疾病的诊断和治疗水平。方法:对21例手术后经病理确诊的中枢神经系统淋巴瘤患者进行外放疗、静脉内化疗和腰椎管蛛网膜下腔化疗。结果:所有患者经上述综合治疗后临床症状迅速好转,神经功能缺失症状明显改善,在随后复诊的CT或MRI图像上肿瘤完全消失。结论:原发性中枢神经系统淋巴瘤采用手术切除,外放疗,静脉化疗和蛛网膜下腔化疗的综合治疗是提高疗效的关键。

BACKGROUND & OBJECTIVES: Primary central nervous system lymphoma (PCNSL) is not common. It represents only 0. 74% of central nervous system tumors in our nation. Diagnosis of PCNSL is difficult. Its treatment result is still unsatisfactory. In this paper, we reviewed 21 patients with PCNSL who re-ceived synthetical treatment in our hospital. METHODS: Twenty-one pathologically confirmed PCNSL patients re-ceived postoperative radiation therapy, intravenous chemotherapy and lumbar intrathecal chemotherapy. RESULTS: In all the patients treated with such synthetical therapy, clinical symptoms were relieved, neurapraxia disappeared,and the tumors also disappeared in follow-up with CT and MRI scan. CONCLUSIONS: It is important for PC-NSL patients to receive a combined treatment of surgery, radiation therapy, systemic chemotherapy and intrathecal chemotherapy.