摘要
γ-羟丁酸钠(Camma-hydroxybutyrate,CHB)具有降低机体脂质过氧化物(LPO)、增加超氧化物歧化酶(SOD)活力的药理机制,本研究以GHB联合放疗(Radiotherapy,RT)治疗恶性脑胶质瘤,以期提高患者生存率。方法:将恶性胶质瘤术后患者36例分为GHB联合RT组和常规放疗组前者于每次放疗前30min给予GHB200mg/m^2静脉滴注,常规放疗1.8～2gy/次,5次/周,处方剂量55～60Gy,后者除不使用GHB外其余同前者。随访观察肿瘤局部控制、生存和急性放射反应情况。Kaplan-Meier方法分析近期疗效、预期生存率结果:GHB+RT组1年、1.5年肿瘤局控率分别为62.20%、26.50%,对照组53.80%、13.80%GHB+RT组平均生存期为21.9±8.26个月,1年、2年预期生存率分别为80.0%、20.0%。对照组平均生存期为14.10±7.75个月,1年、2年预期生存率分别为66.67%、13.33%。GHB+RT组放疗后急性损伤2级、3级发生率分别为22.22%、16.67%,脑水肿、癫痫发生率分别为38.89%、22.22%;对照组急性损伤2级、3级发生率分别为33.33%、27.78%、脑水肿、癫痫66.67%、33.33%。结论:GHB联合放疗治疗恶性脑胶质瘤有助于减少放射反应,提高肿瘤局部控制率。
BACKGROUND & OBJECTIVE: Gamma-hydroxybutyrate (GHB) can reduce lipid peroxida-tion (LPO) and increase superoxide dismutase (SOD). Theoretically, the combination of GHB with radiotherapy(RT) to treat malignant brain glioma may increase the survival rate of these patients. We performed a prospec-tive-randomized study to assess the efficacy of this treatment. METHODS: 36 patients with malignant glioma after surgery was randomly divided into GHB+RT group and routine RT group. The former were treated with GHB 200mg/m^2 iv gtt before RT, RT prescription dose was 60Gy. The latter were treated with routine RT 1.8～ 2. 0Gy/fx, 5fx/weak, prescription dose was 60Gy. We prospectively collected data to analyze tumor control rate(TCR), Kaplan-Meier survival rate and acute radiation response incidence. RESULTS: 1-year and 1. 5-year TGR for GHB+RT group and RT group were 62.20%, 26.60% and 51.40%, 13. 13% respectively. The aver-age survival period was 21.9±8.26 months in the GHB+RT group and 14. 10±7.75 months in the RT group.The expected survival rate at 1 year and 2 year were 80% and 20% in the GHB +RT and 66. 67% and 13.33% in the RT group respectively; the difference was significant. (P<0. 01). Acute response incidence such as cerebral edema was 38. 33% in GHB+RT group and 66. 67% in the RT group. CONCLU-SION: The effect of GHB combined with radiothera-py in treating malignant brain glioma was satisfacto-ry. The early effect and 1 or 2 year survival rate was significant higher and acute radiation reactions was milder in the GBH+RT group as compared with the the RT group. Moreover GHB can reduce the acute radiation reactions.
出处
《中国神经肿瘤杂志》
2003年第4期219-222,共4页
Chinese Journal of Neuro-Oncology
