铜绿假单胞菌对抗生素的耐药性分析

Analysis of Drug Resistance of Pseudomonas Aeruginosa to Different Antibiotic

目的 了解淮南地区铜绿假单胞菌耐药状况 ,为临床合理使用抗生素提供依据。方法 采用常规方法分离、鉴定菌株 ,应用纸片扩散法 (K -B)作 2 0种抗生素对铜绿假单胞菌的体外活性测定。结果 共分离铜绿假单胞菌 386株 ,其对 2 0种抗生素的耐药率依次为 :氯霉素 94 .0 5% ( 79 84 )、复方新诺明 88.2 4 % ( 6 0 6 8)、SMZ -TMP81.6 7% ( 49 6 0 )、呋喃妥因 92 .54 % ( 6 2 6 7)、氨苄青霉素 76 .53% ( 75 98)、头孢唑林 89.31% ( 2 84 318)、头孢呋肟 6 5.31% ( 176 196 )、头孢哌酮 17.6 5% ( 12 6 8)、羧苄青霉素 53.6 6 %( 2 2 4 1)、妥布霉素 4 2 .56 % ( 83 195)、哌拉西林 33.4 6 % ( 88 2 6 3)、头孢他啶 7.2 5% ( 5 6 9)、头孢三嗪 33.80 % ( 48 14 2 )、环丙沙星 14 .81% ( 8 54 )、丁胺卡那 55.81% ( 48 86 )、庆大霉素 6 0 .84 % ( 16 0 2 6 3)、多粘菌素B4 .91% ( 16 32 6 )、氧氟沙星 55.71% ( 39 70 )、诺氟沙星33.33% ( 2 6 78)、阿米卡星 18.82 % ( 16 85)。本菌的多种耐药率约为 35.75% ( 138 386 ) ,不同部位的多重耐药率依次为 :呼吸道 2 6 .98% ( 34 12 6 )、泌尿道 33.33% ( 2 6 78)、血液 4 7.6 9% ( 31 6 5)、皮肤 4 1.6 7% ( 10 2 4 )、伤口创面 4 6 .15% ( 2

Objective To investigate the situation of drug resistance of Pseudomonas aeruginosa, and make proofs for clinical prescriptions. Methods The bacteria were separated, identified, and given drug sensitivity test. Results 386 strains Pseudomonas aeruginosa were acquired, and the drug resistant rates of the bacteria were Chloramphenicol 94.05%(79/84), Compound sinomin 88.24%(60/68),SMZ-TMP 81.67% (49/60), Furantoin 92.54% (62/67), Aminobenzylpenicillin 53.66% (22/41), Cefazolin 88.75% (284/320), Zinacef 89.80% (176/196), Cephanone 17.65% (12/68), Carbenicillin 53.66% (22/41), Tobramycin 42.56% (83/195), Piperacillin 33.46% (88/263), Ceftazidime 7.25% (5/69), Cefatrizzine 38.03% (54/142), Ciprofloxacin l4.81% (8/54), Amikacin 55.81% (48/86), Gentamicin 60.84% (160/263), Polymyxin B 4.91% (16/326), Levofloxacin 55.71% (39/70), Norfloxacin 36.25% (116/320), Amikacin 18.82% (16/85). The multiple drug resistant rates of the bacteria were 35.75% (138/386). Conclusions The first choice medicine in treating the infections of Pseudomonas aeruginosa was Bpolymyxin B, and then are Ceftazidime and Ciprofloxacin. It is unmeet to use Furantoin, cefazolin, chloramphenico and SMZ-TMP in treatment.