纳洛酮治疗急性一氧化碳中毒46例疗效观察

Curative Effect of Naloxone on Acute Carbon Monoxide Poisoning in 46 Cases

目的 观察纳洛酮治疗急性一氧化碳中毒的临床疗效。方法 将 93例急性一氧化碳中毒患者随机分为对照组 ,采用常规治疗 ;治疗组在常规治疗的基础上给予纳洛酮 0 .8mg静注 ,每小时 1次 ,直到清醒或用药至 48小时为止。结果 中重度中毒患者治疗组平均促醒时间分别为 1.5± 0 .3和 9.2± 2 .6小时 ,低于对照组的 3 .6± 0 .8和 12 .8± 4.1小时 (P <0 .0 5～ 0 .0 1)。

Objectives To evaluate the clinical curative effect of naloxone on acute carbon monoxide poisoning in 46 cases. Methods 93 patients of acute carbon monoxide poisoning were divided into 2 groups, the patients were dealt with general treatment in control group. In experimental group, in addition to routine treatment, naloxone(0.8mg) was given by intravenous injection per hour in 48 hours, until the patient waken up. Results The hours, patients spent waking up, were 1.5±0.3(experimental group) and 3.6±0.8(control group), the difference between them is significant(P<0.01). The hours spent in severe patients were 9.2±2.6(experimental group) and 12.8±4.1(control group), the difference between them is significant(P<0.05). Conclusions The clinical curative effect of naloxone on acute carbon monoxide poisoning is obvious.