心脏间隔的形成

Development of Cardiac Septation

心脏形态的建成包括了腔室的形成和间隔的形成两个部分,而心脏间隔的出现又使得心脏从单腔室器官发育成为四腔室的成熟器官.在人类心脏发育过程中,心脏间隔的发生是在胚胎发育的第4周至第7周,在这个过程中,心脏的袢环化以及腔室的逐渐建成,也促进了心脏间隔的形成.心肌层在房室腔的建成中充当了重要的角色,但是研究表明它在心脏间隔的发生中却没有起到实质性的作用,相反对于心外间充质组织,人们开始重新认识它在心脏间隔发生中的意义.

Heart morphogenesis comprises 2 major consecutive steps, viz. chamber formation followed by septation. Cardiac looping and chamber formation bring the contributing structures into position to engage in septation. Cardiomyocytes that participate in chamber formation do not materially contribute to septation. The discovery of the role of extracardiac mesenchymal tissue in atrioventricular septation is recognized.