常用抗生素对部分致病大肠埃希菌的抗菌活性检测

Analysis of Resistance of Antibiotics of Escherichia Coli Straios

目的 通过检测21种常用抗生素对部分致病大肠埃希菌的体外抗菌活性及细菌产β-内酰胺酶情况,以协助临床医生正确选用抗生素治疗大肠埃希菌感染。结果 多数菌株属于多重高度耐药株且产β一内酰胺酶。大部分菌株均耐受青霉素类药物;复方哌拉西林/舒巴坦的抗菌活性则明显提高;舒巴哌酮、第三代头孢菌素的抗菌活性都较高;所有菌株均对碳青霉烯类美罗培南敏感;妥布霉素、新的第三代喹诺酮类中的氟罗沙星和第四代喹诺酮类妥舒沙星、司帕沙星的抗菌活性都较高。结论 使用青霉素类或头抱菌素类时合用酶抑制剂可明显提高疗效;美罗培南的疗效最佳;新的第三代和第四代喹诺酮类的疗效较好。临床医生最好先获得细菌的药敏报告,再选用适当的抗生素进行治疗。

Objective To choose the right antibiotics to cure the infection of Escherichia Coli Strains, we measured the MIC (Minimal Inhibitory Concentration) of 21 antibiotics to strains. The MIC was compared with the β - lactam production of Strains. Results Most strains were multiple - antibiotic - resistant (Mar) strains and can produce β- lactam. Most strains have high resistance to penicillins. When the β - lactam antibiotics and the β- lactam inhibitor are used together, the sensitivity of strains are increased significantly. Most strains have high sensitivity to the 3rd generation Cephacosporin. Meropenem has the best effect on all strains. The newer 3rd generation and the 4th generation Quinolones have good effect on most strains. Conclusion The effective antibiotics should be chosen on the results of susceptible test by the clinic doctors.