长乐市饮食及其他生活习惯与胃癌关系的病例对照研究

Dietary and Other Living Habits and the Risk of Gastric Cancer in Changle, a High - Risk Area in China

目的 探讨饮食及其他生活习惯与胃癌发生的关系。方法1999年1～12月,在胃癌高发区福建省长乐市,收集了310例胃癌新发病例,每个病例配一个同年龄组与性别的对照。调整相对危险度(OR)及其95％可信区间(CI)的估计采用条件Logistic回归。结果 随食用盐渍食品的增加,胃癌的发病危险度亦随之增加(经常与从不吃,OR=2.55,95％ CI=1.04～6.29,趋势检验,P=0.01)。喜烫食、硬食及重盐亦可增加胃癌的发病危险,反之多食禽蛋、新鲜水果、大蒜对胃癌有保护作用。未见食用新鲜蔬菜、吸烟、饮酒、饮茶、冰箱使用与胃癌的关系。结论 食用盐渍食品、喜烫食、硬食及过量摄入食盐可能是胃癌的危险因素,而禽蛋、新鲜水果、大蒜类蔬菜则可能对胃癌有保护作用。

Objective To investigate the relationship between diet, other life - style factors and the risk of gastric cancer. Methods 310 new cases of gastric cancer, and equal number of neighborhood matched by sex and age as the control groups, were collected in Changle, a high- risk area in China, from Jan to Dec in 1999. Adjusted odds ratios (OR)and its 95% confidence intervals (CI)were estimated by conditional logistic regression. Results The risk of gastric cancer increased with the increasing consumption of salted preserved foodstuff (frequent vs never, OR = 2.55,95 % CI = 1.04 - 6.29, P value for trend = 0.01). Preference to hot, hard and salty diet also was associated with increased risk of gastric cancer. By contrast, eggs, fresh fruits and garlic might play some protective role in gatric cancer. NO significant association was found between fresh vegetables, smoking, alcohd drinking, tea drinking and the use of refregerator, and the risk of gastric cancer. Conclusion Salted preserved foodstuff, preference to hot, hard and salty diet might be the risk factors, while eggs, fresh fruits and garlic might be the protective factors for gastric cancer.