摘要
A series of dipeptide derivatives containing non-coded amino acids, N-Boc-4-X-Phe-Ala-NHNHPh (X = Cl, Br, I, NO2), were synthesized by using thermoase in organic solvents. The physical data were consistent with the same samples prepared by 3-(diethoxyphosphoryloxy)-1, 2,3-benzotriazin-4 (3H)-one (DEPBT). Influence of different substituted groups of the noncoded amino acids and different organic solvents on the enzymatic peptide synthesis was studied.
A series of dipeptide derivatives containing non-coded amino acids, N-Boc-4-X-Phe-Ala-NHNHPh (X = Cl, Br, I, NO2), were synthesized by using thermoase in organic solvents. The physical data were consistent with the same samples prepared by 3-(diethoxyphosphoryloxy)-1, 2,3-benzotriazin-4 (3H)-one (DEPBT). Influence of different substituted groups of the noncoded amino acids and different organic solvents on the enzymatic peptide synthesis was studied.
基金
theNationalNaturalScienceFoundationofChina (No.2 9872 0 0 2 )
